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NON-INVASIVE MV. Good news It works !!!!!!!. Warnings Not always Not for all Know the technique Be skilled. i-PSV and n-PSV delivered before and after extubation in patients not weaned. Arterial Blood Gases. pH PaCO 2 PaO 2 /FIO 2. i-PSV 7.38 59.1 206. n-PSV 7.38 61 210.
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NON-INVASIVE MV Good news • It works !!!!!!! Warnings • Not always • Not for all • Know the technique • Be skilled
i-PSV and n-PSV delivered before and after extubation in patients not weaned Arterial Blood Gases pH PaCO2 PaO2/FIO2 i-PSV 7.38 59.1 206 n-PSV 7.38 61 210 T-tube 7.33 69 183 (from Vitacca M. et al. AJRCCM 2001; 164: 638-641)
NON-INVASIVE MV • NIV in the “real-world” • Setting the ventilator • Choice of interfaces • Humidification and drug delivery
NON-INVASIVE MV • NIV in the “real-world” • Setting the ventilator • Choice of interfaces • Humidification and drug delivery
The Use of Noninvasive Ventilation in Acute Respiratory Failure at a Tertiary Care Center* Elizabeth S. Paus-Jenssen, MD; John K. Reid, MD; Donald W. Cockcroft, MD, FCCP; Karen Laframboise, MD; and Heather A. Ward, MD, FCCP Chest 2004; 126: 165-72
60% Hypercapnic 55% Hypoxic
NON-INVASIVE MV • NIV in the “real-world” • Setting the ventilator • Choice of interfaces • Humidification and drug delivery
Appropiate setting for long-term NPSV (n=23 hypercapnic COPD patients) Change (% of SB) (from Vitacca M. et al. Chest 2000)
Assessment of Physiologic Variables and Subjective Comfort Under Different Levels of Pressure Support Ventilation* Michele Vitacca, MD; Luca Bianchi, MD; Ercole Zanotti, MD; Andrea Vianello, MD; Luca Barbano, MD; Roberto Porta, MD; and Enrico Clini, MD, FCCP† Chest 2004; 126: 851-59
V’E, PTP Study protocol SB (baseline) V’E, PTP Pao, IE RANDOM of ventilators comfort 0 setting 10 Time (min)
NON-INVASIVE MV • NIV in the “real-world” • Setting the ventilator • Choice of interfaces • Humidification and drug delivery
Major problems with mask during NIV support Air leaks Side-effects Size
Side effects due to NPPVN=26 (compliant patients) % Mask leaks Skin irritation Rhinitis / aerophagia Discomfort 43 23 13 8 (from Criner GJ. et al. Chest 1999;116:667-675)
MOUTH LEAKS IN NASAL NPPV(n=9, hypercapnic=7, COPD=6, age 64 years) PtcCO2 (mmHg) Arousal Index (events h-1) p<0.001 p<0.0002 (from Teschler H. et al. ERJ 1999; 14: 1251-1257)
Side effects due to NPPVN=26 (compliant patients) % Mask leaks Skin irritation Rhinitis / aerophagia Discomfort 43 23 13 8 (from Criner GJ. et al. Chest 1999;116:667-675)
Esperienza dell’équipe Considerazioni anatomiche CRITERI PER LA SCELTA DELLA MASCHERA Compliance e sensorio del paziente Modalità di ventilazione
NON-INVASIVE MV • NIV in the “real-world” • Setting the ventilator • Choice of interfaces • Humidification and drug delivery
In the present pilot study, the use heated humidification and heat and moisture exchanger showed similar tolerance and side-effects, but a higher number of patients decided to continue long-term noninvasive mechanical ventilation with heated humidification.
To conclude, when using noninvasive positive pressure ventilation with two-level respirators, oxygen should be added close to the exhaust port (ventilator side) of the circuit. If inspiratory airway pressure levels are >12 cmH2O, oxygen flows should be at least 4 L*min-1
Respir Care 2004;49(3):270–275. CONCLUSIONS Delivered oxygen concentration during BiPAP is a complex interaction between the leak port type, the site of oxygen injection, the ventilator settings, and the oxygen flow. Because of this, it is important to continuously measure arterial oxygen saturation via pulse oximetry with patients in acute respiratory failure who are receiving noninvasive ventilation from a bi-level ventilator.