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Stage 0

Stage 0. Occipital. Frontal. Stage 1. trans-entorhinal cortex. trans-entorhinal cortex. Stage 2. Entorhinal cortex. Entorhinal cortex. likely asymptomatic. Stage 3. Hippocampus. Hippocampus. possible MCI. Stage 4. Temporal pole. Temporal pole (BA 38). probable MCI. Stage 5.

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Stage 0

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  1. Stage 0 Occipital Frontal

  2. Stage 1 trans-entorhinal cortex trans-entorhinal cortex

  3. Stage 2 Entorhinal cortex Entorhinal cortex likely asymptomatic

  4. Stage 3 Hippocampus Hippocampus possible MCI

  5. Stage 4 Temporal pole Temporal pole (BA 38) probable MCI

  6. Stage 5 inferior temporal cortex very probable MCI

  7. Stage 6 mid temporal cortex mid temporal cortex Subtle but significant cognitive impairment

  8. Stage 7 polymodal association cortex polymodal association cortex First stage of clinical Alzheimer’s disease

  9. Stage 8 Broca area(BA 44) Intermediate stage of AD

  10. Stage 9 Unimodal areas Unimodal areas Moderate to severe AD

  11. Stage 10 All neocortical areas are affected, and many subcortical areas as well Last stage of AD

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