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Stage 0. Occipital. Frontal. Stage 1. trans-entorhinal cortex. trans-entorhinal cortex. Stage 2. Entorhinal cortex. Entorhinal cortex. likely asymptomatic. Stage 3. Hippocampus. Hippocampus. possible MCI. Stage 4. Temporal pole. Temporal pole (BA 38). probable MCI. Stage 5.
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Stage 0 Occipital Frontal
Stage 1 trans-entorhinal cortex trans-entorhinal cortex
Stage 2 Entorhinal cortex Entorhinal cortex likely asymptomatic
Stage 3 Hippocampus Hippocampus possible MCI
Stage 4 Temporal pole Temporal pole (BA 38) probable MCI
Stage 5 inferior temporal cortex very probable MCI
Stage 6 mid temporal cortex mid temporal cortex Subtle but significant cognitive impairment
Stage 7 polymodal association cortex polymodal association cortex First stage of clinical Alzheimer’s disease
Stage 8 Broca area(BA 44) Intermediate stage of AD
Stage 9 Unimodal areas Unimodal areas Moderate to severe AD
Stage 10 All neocortical areas are affected, and many subcortical areas as well Last stage of AD