1 / 11

Lecture 20 - Association Tests

Lecture 20 - Association Tests. Gibson and Muse, Chapt. 3, 2nd Ed. Association Populations. Case-Control - unstructured populations Family-Based - structured populations Continuous variable - structured and/or unstructured. Pitfalls of Association Tests. Trait h 2

kolya
Download Presentation

Lecture 20 - Association Tests

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Lecture 20 - Association Tests • Gibson and Muse, Chapt. 3, 2nd Ed.

  2. Association Populations • Case-Control - unstructured populations • Family-Based - structured populations • Continuous variable - structured and/or unstructured

  3. Pitfalls of Association Tests • Trait h2 • Number of genes effecting trait • Penetrance and expressivity • Extent and uniformity of LD • Genetic heterogeneity • Population stratification • Admixture • Hidden environmental structure • GxE and GxG • Incomplete genotyping

  4. Genomewide AssociationModel-Free & Unbiased cases controls M1 M4 M5 M2 M3 M4 M1 M2 M3 M5 causal mutation

  5. Pug Dog Encephalitis A canine model of Multiple Sclerosis? • CNS Inflammation & Necrosis • Early Onset = 1.5 yrs • Fatal = 3 weeks • Complex Inheritance

  6. Pug Dog Encephalitis A canine model of Multiple Sclerosis? cases controls M1 M2 M3 M4 M5 M1 M2 M3 M4 M5

  7. A Review • Lecture 11 - ESTs • Lecture 12 - Genetic markers • Lecture 13 - Genetic mapping • Lecture 14 - Complex traits • Lecture 15 - QTL mapping • Lecture 16 - SNP discovery • Lecture 17 - Nucleotide diversity and LD • Lecture 18 - Tests for selection • Lecture 19 - SNP genotyping • Lecture 20 - Association mapping

More Related