ICR’s Activities in Cancer Imaging

1. ICR’s Activities in Cancer Imaging Institute of Cancer Research - Institut du cancer

2. Funding Sources for Imaging Research in Canada Federal • Canadian Institutes of Health Research (CIHR) • Natural Science and Engineering Research Council (NSERC) • Canadian Foundation for Innovation (CFI) • National Research Council (NRC) • Natural Resources Canada (NRCan) • Canada Research Chairs (CRC) • Canada Excellence Research Chairs (CERC) • Networks of Centres of Excellence (NCE) • Centres of Excellence for Commercialization and Research(CECR) Other • Cancer – Canadian Cancer Research Alliance (CCRA) Provinces (Alberta Innovates, OICR); NGOs (CCS, TFRI) Institute of Cancer Research - Institut du cancer

3. CIHR • Created in 2000 to replace the Medical Research Council • CIHR is Canada’s federal funding agency for health research • CIHR’s mission is to create new scientific knowledge and to enable its translation into improved health, more effective health services and products, and a strengthened Canadian health care system. • CIHR supports more than 13,200 health researchers and trainees across Canada • CIHR funds both investigator-initiated research as well as research on targeted priority areas • CIHR builds research capacity in under-developed areas and training the next generation of health researchers • CIHR focuses on knowledge translation that facilitates the application of the results of research and their transformation into new policies, practices, procedures, products and services • CIHR operates with a $1 billion annual budget • CIHR has 13 virtual Institutes Institute of Cancer Research - Institut du cancer

4. Canadian Institutes of Health Research (CIHR) Institute of Cancer Research - Institut du cancer

5. In the beginning ……… Institute of Cancer Research - Institut du cancer

6. Bringing a community together Institute of Cancer Research - Institut du cancer

7. Outcomes of the first workshop • Brought the oncology, cardiology and neurology imaging communities together • Provided a series of recommendation for addressing the challenges in imaging • Led to $10M, in Budget 2010, to support the first national imaging clinical trials network – MITNEC • MITNEC now coordinating clinical trials on the new products produced in the Isotope initiative Institute of Cancer Research - Institut du cancer

8. Making International Connections Institute of Cancer Research - Institut du cancer

9. Imaging Workshop – Canada/US/UKLinking ‘omics to Patient care Through Imaging • The workshop was jointly organized by CIHR-ICR, NCI and CRUK and hosted by the Canadian High Commission in London, UK • The event brought together leading academic imaging and molecular science researchers from Canada (9); the UK (12); and the US (10), as well as organizing committee members, program staff and representatives of other UK research agencies • The goal of the workshop was to assess the feasibility of combining imaging expertise, resources and infrastructures among the three countries • The workshop included keynote presentations (two from each country); short presentations from participating researchers; a series of three breakout sessions; and informal networking opportunities • Discussions focused on finding common solutions to the existing barriers to translational research in cancer imaging Institute of Cancer Research - Institut du cancer

10. Key Recommendations from the Canada/US/UK Workshop The workshop generated great enthusiasm for the development of Canada/UK/US collaborations that could address an identified need to: • Optimize and validate innovative imaging platforms and methods that meet the sensitivity and specificity performance requirements for specific cancer problems • Provide robust quantitative measurements (as opposed to traditional qualitative methods), and optimize these methods for more efficient large-scale metadata analysis, and correlation with other research domains such as genomics, epigenetics, proteomics and other laboratory biomarker measurements. • Promote Interdisciplinary research in imaging and molecular sciences so more effective molecular or mechanistic-based solutions for data integration across the three imaging research domains can be explored and shared both nationally and internationally. Institute of Cancer Research - Institut du cancer

11. Development of a Management Plan Funding Opportunity: Quantitative Imaging for Prediction and/or Evaluation of Responses to Cancer Therapies The six-page Management Plan covered: • Goals of the program – establish two Canadian teams as an integral part of QIN • Program delivery model – submit directly to NIH • Funding opportunity announcement – CIHR website, NIH Guide for Grants and Contracts • Relevance review – NCI program staff, CIHR for eligibility check of applicant • Review of full applications – NIH and NCI policies and procedures, CIHR observer • QIN executive committee – CIHR representative on QIN Executive Committee • Communications – NCI and CIHR, French and English, for CIHR formal news releases through Canadian Minster of Health • Ownership of IP - awardees • Access to Information and privacy act - according to national regulations • Termination – provide notice in writing, meet to discuss future of program • Dispute resolution - resolved jointly by NCI and CIHR • Agreement non-legally binding • Collaboration • Contact information Institute of Cancer Research - Institut du cancer

12. Funding Opportunity: Quantitative Imaging for Prediction and/or Evaluation of Responses to Cancer Therapies • September 2013 - Alert imaging research community to the upcoming call • October 2013 – Post funding opportunity on CIHR website with links to the NIH websites • November 2013 – Webinex for interested researchers • Applications due February 2014 • ICR, in partnership with Genome BC, will provide funding to support up to two Canadian QIN nodes for five years • Investment will be up to $400,000 per node per annum – this aligns well with the funding for the US nodes • Program will be run by the NIH through their regular processes. • The top two fundable Canadian applications will be funded Institute of Cancer Research - Institut du cancer

13. Canadian Participation in QIN As permitted under existing laws, regulations and policies the Canadian teams will participate in and contribute to: • QIN research activities • collaborative working groups • consensus publications • monthly teleconferences • annual and semi-annual meetings • other participatory activities of the Network Institute of Cancer Research - Institut du cancer

14. Going Forward Institute of Cancer Research - Institut du cancer

15. We’re growing! Institute of Cancer Research - Institut du cancer