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Advanced Statistics for Interventional Cardiologists

Advanced Statistics for Interventional Cardiologists. What you will learn. Introduction Basics of multivariable statistical modeling Advanced linear regression methods Hands-on session: linear regression Bayesian methods Logistic regression and generalized linear model Resampling methods

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Advanced Statistics for Interventional Cardiologists

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  1. Advanced Statistics for Interventional Cardiologists

  2. What you will learn • Introduction • Basics of multivariable statistical modeling • Advanced linear regression methods • Hands-on session: linear regression • Bayesian methods • Logistic regression and generalized linear model • Resampling methods • Meta-analysis • Hands-on session: logistic regression and meta-analysis • Multifactor analysis of variance • Cox proportional hazards analysis • Hands-on session: Cox proportional hazard analysis • Propensity analysis • Most popular statistical packages • Conclusions and take home messages 1st day 2ndday

  3. There are only 10 attitudes towards binary numbers: There are only 10 attitudes towards biostatistics:

  4. There are only 10 attitudes towards binary numbers: either you understand them or not There are only 10 attitudes towards biostatistics: either you practice it or you ignore it

  5. Standard statistics is just like standard PCI • Nobody was accomplished and quick the first time he took a guiding (or even diagnostic!) catheter in hand: now look at yourself and what you have done in interventional cardiology! • Keep on criss-crossing between published papers, your own data, your own analyses and chit-chat with colleagues or (even would-be) expert: it helps a lot on the long-term • Keep focused and work on what you like and what you need

  6. Adanced statistics is just like advanced PCI • For any advanced technique, the best initial approach is partnering with an expert and learn case by case • Even if you are experienced with a given approach, you might need supervision for other similarly complex techniques • Advanced statistics is all too similar: learn to enjoy the road and pursue as much as possible open collaboration and constructive criticisms

  7. Helpful books • Multivariable Analysis: A Practical Guide for Clinicians, by Katz, 2006 • Regression Methods in Biostatistics: Linear, Logistic, Survival, and Repeated Measures Models, by Vittinghoff, Glidden, Shiboski, and McCulloch, 2007 • Introduction to Analysis of Variance: Design, Analysis & Interpretation, by Turner and Thayer, 2001 • Bayesian Approaches to Clinical Trials and Health-Care Evaluation, by Spiegelhalter, Abrams, and Myles, 2004 • Applied logistic regression, by Hosmer and Lemeshow, 2000 • An Introduction to the Bootstrap, by Efron and Tibshirani, 1994 • Monte Carlo Simulation, by Mooney, 1997 • Systematic Reviews in Health Care: Meta-Analysis in Context, by Egger, Davey Smith, and Altman, 2001 • Survival Analysis, by Klein and Moeschberger, 2005 • A Step-by-Step Approach to Using SAS for Univariate and Multivariate Statistics, by O'Rourke, Hatcher, and Stepanski, 2005 • Discovering Statistics Using SPSS, by Field, 2005

  8. Helpful websites • http://faculty.vassar.edu/lowry/anova1u.html: I useitroutinely to do ANOVA online • http://home.clara.net/sisa/index.htm: thoroughbut easy going, focused on analyses and sample sizecomputations • http://members.aol.com/johnp71/javastat.html: withmanyusefullinksforstatisticalanalyses and sample sizecomputations • http://www.angelfire.com/wv/bwhomedir/: thorough personal webpage (Bruce Weaver’s) full oflinksforadvancedstatisticalmethods • http://www.bayesian.org/: forthosewitha genuine interest in Bayesiananalysis • http://www.cdc.gov: providesEpi-Info and StatCalcfreewares • http://www.cytel.com/: provides trial programsforexactanalyses • http://www.geocities.com/CollegePark/Quad/2435/: tips and tricksfor Monte Carlo • http://www.metcardio.org: forthosewith a specific interest in meta-analyses • http://www.quantitativeskills.com/sisa/statistics/twoby2.htm: I useitroutinely to do chi-square and Fisher exacttests online • http://www.randomization.com: ideal to create yourownrandomizationlists • http://www.resample.com/content/software/excel/download.shtml: providestoolsforhome-made resampling analyses • http://www.statsdirect.com/: provides trial programforbootstrap • http://www.virtualstatistician.com/link-63.html: verycomprehensive, sometimestoofocused on methods and dry

  9. Questions?

  10. And now…

  11. For further slides on these topics please feel free to visit the metcardio.org website:http://www.metcardio.org/slides.html

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