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Biopharmaceutics

Biopharmaceutics. refers to the relationship of the: * physicochemical property of the drug * dosage form in which the drug is given * route of administration *extent of systemic absorption of the drug involves factors that influences the: * protection of the activity of drug

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Biopharmaceutics

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  1. Biopharmaceutics • refers to the relationship of the: • * physicochemical property of the drug • * dosage form in which the drug is given • * route of administration • *extent of systemic absorption of the drug • involves factors that influences the: • * protection of the activity of drug • * release of drug from the drug product • * rate of dissolution of drug at the • absorption site

  2. PHARMACOKINETICS -involves the kinetics of drug liberation, absorption, distribution, elimination and response or the LADMER system. Liberation- determines the onset of action, rate of absorption and availability of all routes of administration, except IV. Tablet dissolution is the ability of a drug preparation to dissolve. (insert diagram)

  3. Pharmacokinetics involves: • Experimental Aspect • - development of biological sampling techniques • analytical methods for the measurement of drug and metabolites • procedures that facilitate data collection and manipulation B. Theoretical Aspect - development of pharmacokinetic models that predict drug disposition after drug administration.

  4. is a hypothesis that uses mathematical terms that concisely describe quantitative relationships. • Describes complex biologic system concerning the movement of drugs • Used to simulate the rate processes of drug absorption, distribution and elimination. • Describes the drug concentration in the body as a function of time.

  5. Pharmacokinetic Models • Empirical Model • - are practical but not very useful in explaining the mechanism of the actual process by which the drug is absorbed, distributed and eliminated in the body. • 2. Physiological Model • - interpolates the data and allow a formula toestimate drug levels over time when limited information is available. • - it reveals an organ specific or sub-organ regional information and assume that the plasma drug concentration globally within the body.

  6. Why Molecular Models are being used? • Predicts plasma, tissue and urine drug level with any dosage regimen. • Calculates the optimum dosage regimen for each patient. • Estimates the possible accumulation of drugs. • Correlate drug concentrations with pharmacologic or toxicologic activity. • Evaluates differences in the rate or extent of availability between formulations. • Describe how changes in physiology of disease affects absorption, distribution or elimination of drugs. • Explains drug interaction.

  7. Different Compartment Models A. MAMMILLARY MODEL • One-Compartment Open Model through IV • - is the simplest way used to describe the process of • drug distribution and elimination of the body. • 2. Multi-Compartment Model • - highly perfused tissue and blood makes up the • central compartment.

  8. Different Compartment Models B. CATENARY MODEL - consist of compartments joined to one another like the compartments of a train. C. PHYSIOLOGIC/FLOW/PERFUSION MODEL - based on the known anatomic and physiologic data.

  9. GENERAL GROUPING OF TISSUE ACCORDING TO THE BLOOD SUPPLY

  10. DISTRIBUTION What happened to the medicine after it is absorbed? A D M E Absorption Metabolism Excretion Distribution (tissue bound)

  11. Polar Compounds Polar Compounds reabsorb from the kidney excreted URINE FAT TISSUE DRUG ELIMINATION

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