1 / 1

TRPV1

MOLECULAR BASIS & REGULATION OF TRPV1 ACTIVITY. Bradykinin B 2 PAR2 P 2 Y. PGE 2. EP1 EP2. NGF. cAMP. AEA NADA. TrkA. 12-( S )-HPETE 15-( S )-HETE LTB 4. PKA. +. PKC. +. α. βγ. +. +. +. +. IP3. ?. +. DAG. Ca 2+. AC. Ca 2+. Ca 2+. PIP2. C. PLC. P. N. Gs.

ksena
Download Presentation

TRPV1

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. MOLECULAR BASIS & REGULATION OF TRPV1 ACTIVITY Bradykinin B2 PAR2 P2Y PGE2 EP1 EP2 NGF cAMP AEA NADA • TrkA 12-(S)-HPETE 15-(S)-HETE LTB4 PKA + PKC + α βγ + + + + IP3 ? + DAG Ca2+ AC Ca2+ Ca2+ PIP2 C PLC P N Gs Ethanol TRPV1 Low pH (5-6) Temperature (>43ºC)

More Related