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Marom Bikson

Network oscillations as a substrate for tACS modulation of learning and plasticity: cellular and quantitative insights from brain slice Gottingen, March 18, 2013. Marom Bikson

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Marom Bikson

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  1. Network oscillations as a substrate for tACS modulation of learning and plasticity: cellular and quantitative insights from brain sliceGottingen, March 18, 2013 Marom Bikson Lucas Parra, Dennis Truong, Abhishek Datta, Davide Reato, Asif Rahman, Belen Lafon, Thomas Radman, Jacek Dmochowski, Preet Minhas, Yu Huang, Mahtab Alam, Alexander David, Peter Toshev, Ole Seibt Department of Biomedical Engineering, The City College of New York, New York, NY $ NIH, NSF, Epilepsy Foundation, Wallace Coulter Foundation, DoD (AFOSR)

  2. tACS current flow : alternating direction

  3. tACS current flow : alternating direction

  4. tACS current flow : alternating direction

  5. tACS current flow : alternating direction

  6. tACS dose: Waveform • Maximum polarization at DC is 0.15 mV per mA current(Bikson et al. J. Physiol. 2004, Radman et al. Brain Stim. 2009) • Sensitivity decrease with frequencies >20 Hz (Bikson et al. J. Physiol 2004) + Peak Memrane Polarization + 5 Hz 50 Hz Frequency 500 Hz 5000 Hz DC (0 Hz) • Neurons become insensitive “transparent” to current at >500 Hz (Bikson et al. J. Physiol 2001)

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