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Research Methods Lecture 1 Objectives Today. Orientation to class Orientation to Professional Expectations First lecture on content First lab First homework (due today). PROFESSIONALISM IN PHYSICAL THERAPY: CORE VALUES. 1. Accountability 2. Altruism 3. Compassion/Caring 4. Excellence
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Research Methods Lecture 1Objectives Today • Orientation to class • Orientation to Professional Expectations • First lecture on content • First lab • First homework (due today)
PROFESSIONALISM IN PHYSICAL THERAPY: CORE VALUES • 1. Accountability • 2. Altruism • 3. Compassion/Caring • 4. Excellence • 5. Social Responsibility • 6. Integrity • 7. Professional Duty
First RM Lecture Is the data relevant? • What is wrong with this question? • Subject verb agreement
First RM Lecture • Test/Measure – used to obtain a measurement • An attribute – a variable, a characteristic, a quality • An examination – a test or tests • An evaluation – a judgment • Operational definition – provides a common framework
Clinical Research • Quest to be Evidence-Based Profession • Our Practice (every patient we treat) should be • Backed up by research/data • Using the current best evidence • Why?
Clinical Research • Structured process • Empirical and critical= able to observe it • Framed by our societal/professional paradigms • Outcomes important • Health and disability models are frame of reference • Practice should be Evidence-Based • Research is Careful, Logical, and Systematic
Clinical Research • Research is Careful, Logical, and Systematic • It does not prove • It can lend support (for or against) • Research is repeatable • Must be to be reliable and hence valid
Measuring Outcomes • Did the patient live? • Did impairments lessen? • Did functional limitations lessen? • Did health improve? • Did we save money? • Did we save time? • Health Related Quality of Life (HRQOL) • SF-36 • WOMAC • ODI
Models of Health and Disability • Nagi model • Pathology, Impairment, Functional Limitation, Disability • International Classification of Function • “Ability” slant to the Nagi model • Capacity vs Performance • Provide a framework for relevant outcome measures • Figure 1.1 in P & W good summary models
Evidence-Based Practice • Sackett a giant in this field • “integration of best research evidence with our clinical expertise and our patient’s unique values and circumstances” • Ask an answerable question • PICO one way of framing a question • Then look to the literature
One Way to Ask a Question • Population of interest • Intervention you are considering • Control/Comparison Treatment • Outcome that you will measure
Sources of Knowledge • Tradition: least powerful* • Authority • Trial and Error • Logic • Deductive • Inductive • Scientific Method Assumptions: most powerful* • Nature is orderly • Events not random • Limitations in our profession?
Research • A continuum (Fig 1.5 P&W) • Case Study • Randomized Controlled Trials • Everything in between • Research process • Identify the question/topic (general) “PICO” • Design the Study • Search the literature • Define the topic (specific) • State a general question • Operationally defined hypothesis • Methods (collect and reduce data) • Analyze • Communicate
Measurement • Continuously • How tall are you? • Discretely • What is my heart rate? 60 ¾ bpm vs 60 bpm • Are you male or female? XX XY YY, more than 2 • Dependent of our ability to define • Measurement often indirect= HR measured in pulse or BP is in cuff • Precision: number of decimal points vs. Accuracy: • Amount and units (22 inches) need to have units
Nominal Dataaka Categorical Data • “3 vs 4 categories” • Finite number of classifications= can code with a label for ease, but has no meaning. • Categories • Mutually exclusive= cant be both male or female, one result. • Exhaustive • Numbers or symbols may be assigned • Have no inherent value • Can be changed without affecting the data • Counting is the only math allowed! = no averages taken
Ordinal Data • Rank ordered, 1st step, 2nd step, etc. • Those of the same rank not required to be equal • Ranks are not equally spaced • May or may not have true zero point • Averaging is allowed • But the value doesn’t reflect a true quantity • Most common ordinal scale is Likertscale “1 = Very satisfied, 2 = satisfied, 3 = neutral….” *not a true quanity
Continuous Data“Scale” Data in PASW1 scale covers 2 scales • Interval and ratio data are here • Difference is presence of true zero, interval has no 0 • Like the temperature scale 0, 32, 273 • Can be broken into smaller pieces –continuously
Interval Scale • Rank ordered • Ranks are equally spaced • No true zero point • Transformation cannot be done directly • Transformation can be done while retaining relative positions • Mathematical operations should not include intervals because there is no true zero)
Ratio Scale • Rank ordered • Ranks are equally spaced • There is a true zero point • All mathematical operations permissible
The Research Question • More important than ability as statistician • Requires refinement to answerable question • Topic • Research Problem • Research Question • Research Question shaped by: • Clinical experience (no substitute for this) • Feasibility and importance • Population to be sampled • Rationale • Variables to consider
The Variables • Independent (IV in this course) • The predictor = usually the treatment or time • Can have more than one • Always at least two levels for each independent variable • Dependent (DV in this course) • The outcome • Can have more than one DV= multiple outcomes, ROM, Strength, pain • No levels, EVER, EVER, EVER (not even 1)
In class practice=both for most • Strength=either • Nerve Conduction Velocity=dependent • Age=independent • Employment status=both; predict scores on disability index
The Hypotheses • Research hypotheses • True expectation • What you think is the answer to your question • There will be a difference from intervention, but can be a dull sometimes • Statistical (null) • No difference/no relationship between IV and DV, when we want to show that there is no difference like drug vs exercise • Directional (difference will be in a specific direction) easier to find a difference in A will be bigger than B • Non-directional (only that there will be a difference) is there difference in either smaller or bigger • Simple (One IV (infinite levels) and One DV (infinite outcomes, no levels!!)) • Complex (more than one IV and or DV)
The Literature • Review it every step of the way (Fig 7.1 P & W) • Differentiate your sources • Primary sources • Peer reviewed journal articles • Oral presentations from the researcher • Interviews • Personal experience • Secondary sources • Textbooks (good source of citations of primary sources) • Review articles
Measurements • NIOR