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Wilcock G., Möbius H.J., and Stöffler A. on behalf of the MMM 500 group

A Double-blind, Placebo-controlled Multicentre Study of Memantine in Mild to Moderate Vascular Dementia (MMM 500). Wilcock G., Möbius H.J., and Stöffler A. on behalf of the MMM 500 group Int Clin Psychopharmacol 2002, 17(6):297-305. Study Design. No. of patients N = 579

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Wilcock G., Möbius H.J., and Stöffler A. on behalf of the MMM 500 group

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  1. A Double-blind, Placebo-controlled Multicentre Study of Memantine in Mild to Moderate Vascular Dementia (MMM 500) Wilcock G., Möbius H.J., and Stöffler A. on behalf of the MMM 500 group Int Clin Psychopharmacol 2002, 17(6):297-305

  2. Study Design No. of patients N = 579 Design Double-blind, randomized, placebo- controlled, multicenter study Diagnosis Probable VaD (HIS score  4, DSM-III-R, NINDS-AIREN) Age  54 years (mean 77) Severity MMSE 10 - 22 (mean 17.6) Dose; duration 20 mg memantine/day; 28 weeks Primary efficacy Cognition: ADAS-cogparameters Global: CGI-C Secondary efficacy MMSE, GBS, NOSGER, parameters Wilcock et al., Int Clin Psychopharmacol 2002

  3. 2 0 -2 -4 *  Memantine (20 mg/day)  Placebo 0 12 28 Significant Benefit of Memantine on Cognition (ADAS-cog) ITT, LOCF Mean change from baseline Improvement ADAS-cog score difference Worsening Week *p < 0.05 versus placebo Wilcock et al., Int Clin Psychopharmacol 2002

  4. Summary • Significant cognitive benefit for memantine treated patients in mild to moderate vascular dementia • Good safety and tolerability of memantine Wilcock et al., Int Clin Psychopharmacol 2002

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