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Mode of Action

Mode of Action. 5FU. MTX. Pemetrexed. TS Thymidylate synthase DHFR Dihydrofolate reductase GARFT Glycinamide ribonucleotide formyltransferase. Multi target antifolate. Folic acid. GAR = glycinamide ribotide. Dihydrofolate reductase. Dihydro-folate (DHF).

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Mode of Action

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  1. Mode of Action 5FU MTX Pemetrexed TS Thymidylate synthase DHFR Dihydrofolate reductase GARFT Glycinamide ribonucleotide formyltransferase Multi target antifolate

  2. Folic acid GAR = glycinamide ribotide Dihydrofolate reductase Dihydro-folate (DHF) Pemetrexed 5-Glutamate PRPP Pemetrexed Pemetrexed 5-Glutamate Tertra-hydro-folate (THF) GAR Thymidilate synthase FGAR N10 Formyl THF N5N10 methylene THF dTDP dTMP Pemetrexed 5-Glutamate AMP dUMP AICAR GMP FAICAR dTTP AICAR=Aminoimidazole carboxamide Ribotide GARFT AICARFT 2 DNA FT=Formyl transferase

  3. Folic acid Dihydro-folate (DHF) Thrombosis Tertra-hydro-folate (THF) Hypercoagulable state N10 Formyl THF N5N10 methylene THF Toxic to endothelial cells Inhibits NO Increases platelet activation Induces tissue factor Activates factor V Inhibits protein C MTHFR THF N5 Methyl THF Homocysteine Methionine Can we detect those who will experience toxicity to Pemetrexed?

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