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DNA: Discovery & Replication. Does DNA = genes?. DNA is in the nucleus DNA is in the nucleus of all species looked at each species has it’s own ‘amount’ of DNA Somatic cells have twice the DNA as gametes. Rosalind Franklin: July 25, 1920 – April 16, 1958. Maurice Wilkins:
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Does DNA = genes? DNA is in the nucleus DNA is in the nucleus of all species looked at each species has it’s own ‘amount’ of DNA Somatic cells have twice the DNA as gametes
Rosalind Franklin: July 25, 1920 – April 16, 1958 Maurice Wilkins: December 15, 1916 – October 5, 2004
Figure 10.3C Twist
Figure 10.3D_2 Hydrogen bond G C T A A T C G Partial chemicalstructure
Figure 10.5B 3 end 5 end P HO 5 2 4 T A 3 3 1 1 4 2 5 P P C G P P G C P P T A OH P 5 end 3 end
3C 5C 5C 3C http://cm3.missiondata.com/uploads/43/Image/dna%20101/dna-pairs.jpg
Figure 10.4A_s1 A T C G G C A T T A A parentalmoleculeof DNA
Figure 10.4A_s2 T A T A A T C G C G G C G C G C C A A T T A Freenucleotides T A T A A parentalmoleculeof DNA The parental strandsseparate and serveas templates
Figure 10.4A_s3 T A T A T A T A A T C G C G C G C G G C G C G C G G C C C A A T A T T A A T Freenucleotides T A T A T A T A A parentalmoleculeof DNA The parental strandsseparate and serveas templates Two identicaldaughter moleculesof DNA are formed
Figure 10.5C 3 DNA polymerasemolecule This daughterstrand is synthesizedcontinuously 5 Parental DNA 5 3 Replication fork This daughterstrand is synthesizedin pieces 3 5 http://www.youtube.com/watch?v=5VefaI0LrgE&feature=related 5 3 DNA ligase Overall direction of replication