I ndiana Institute For Personalized Medicine

1. Indiana Institute For Personalized Medicine David A Flockhart MD, PhD Professor of Medicine, Genetics and Pharmacology Indiana University

2. Challenges for Personalized Medicineas a Health Care Solution • Genomics has not delivered • Proteomics has not delivered • Bioinformatics has not delivered • Small and Dry Pharmaceutical Pipelines • Effective Electronic Medical Records are Rare Events

3. It’s Been Ten Years • . F S Collins Science 2011;331:546-546

4. “the once-hypothetical medical benefits of individual genome sequencing are beginning to be realized in the clinic.” • ….in fact, it's one of the many reasons that NIH plans to create a National Center for Advancing Translational and Therapeutic Sciences • F S Collins Science 2011;331:546-546

5. “If I could move the clock back to 2001 and change course, I would invest significantly more in developing large clinical resources with detailed, individual clinical histories, deep phenotyping, and longitudinal follow-up in order to better understand outcomes and treatment responses” • Tom Hudson, Science 2011;331:547

6. The Genome Wide Association barrier : 282 Genome Wide Association StudiesPublished in Peer-Reviewed Journals since January 2007

7. Genome Wide Association as a tool for predictive medicine • Fletcher R, Flockhart DA, 2010

8. Genome-wide association study identifies 6 novel breast cancer susceptibility lociNature May 27th, 2007 • 1.27 fold = the risk conferred by 1 glass of wine per day

9. Tools for Personalized Medicine in Indiana • A Robust Electronic Medical Record with Long Follow Up • A Biobank of Samples that Links to the EMR • Genomic and Pharmacogenomics Expertise • Imaging Expertise • Informatic Expertise • Center for Computational Biology • Modeling Expertise • CTSI Disease and Therapeutics Modeling Program • Trained Professionals • Strategic Partnerships with Implementers

10. Implementers of Personalized Medicine • Patients • Physicians • Pharmacists • Nurses • Diagnostic Companies • Pharma Companies • Biotech

11. Indiana Institute For Personalized Medicine • Founded January 1st, 2011 • Schools of Medicine, Nursing and Informatics, IU Cancer Center and the Regenstrief Institute • Open to all IU Faculty • New Brater Fellowships in Personalized Medicine • New Pilot funding • New Faculty

12. Brater Scholar Program • A Mentored Program to Prepare Physician Scientists for Careers in Personalized Medicine • Emphasis on Peer Collaboration Among Fellows • Salary supplement • $ for supplies and travel

13. 2011 Brater Scholars in Personalized Medicine • Troy Quigg MD, Pediatric Oncology • Vic Senadhi MD, Division of Gastroenterology • Jody Skiles, Department of Pediatrics

14. Indiana Biobank: Goals • To create a statewide, robust collection of biological samples • To be accessible to basic and clinical investigators as a research tool • To enroll and collect samples from 50,000 patients in 5 years

15. Indiana Biobank: Purpose Established in July 2010 50,000 high quality samples in 5 years linked to the electronic medical record and to genomic and proteomic data. • Available to basic and clinical researchers. • Patients from Clarian Health, Wishard and other clinical venues throughout Indiana: a Key Research Arm of the IU Health system Anne Nguyen CCRP

16. Academic Strategic Partnerships • Department of Medicine • Department of Pediatrics • PREGMED • Center for Pediatric Clinical Therapeutics • Department of OB/GYN • IU Cancer Center • Center for Computational Biology • Department of Radiology • Regenstrief Institute

17. Targeted Areas for Strategic Partnerships • Diagnostics Organizations • Therapeutics Organizations • International: • Kenya • China • NIH • FDA

18. Indiana Institue For Personalized Medicine Leadership Lang Li PhD Computational Biology Anne Nguyen CCRP Indiana Biobank Bryan Schneider MD IU Cancer Center Jamie Renbarger MD, MS Pediatrics