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Optimalizácia vlastností Sky TKI inhibítorov na báze 2,4-diaminopyrimidín-5-karbamidu

Optimalizácia vlastností Sky TKI inhibítorov na báze 2,4-diaminopyrimidín-5-karbamidu. Mgr. Peter Šramel, Katedra organickej chémie, PriF UK. Arteriálna trombóza. www.med.unc.edu. 2,4-diaminopyrimidín-5-karbamidy. 2,4-diaminopyrimidín-5-karbamidy. Syntéza analógov (4 – 12).

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Optimalizácia vlastností Sky TKI inhibítorov na báze 2,4-diaminopyrimidín-5-karbamidu

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  1. Optimalizácia vlastností Sky TKI inhibítorov na báze 2,4-diaminopyrimidín-5-karbamidu Mgr. Peter Šramel, Katedra organickej chémie, PriF UK

  2. Arteriálna trombóza www.med.unc.edu

  3. 2,4-diaminopyrimidín-5-karbamidy

  4. 2,4-diaminopyrimidín-5-karbamidy

  5. Syntéza analógov (4 – 12) Powell, N. A. et al. Bioorg. Med. Chem. Lett. 2013, 23, 1051 – 1055.

  6. Syntéza analógov (15 -19) Powell, N. A. et al. Bioorg. Med. Chem. Lett. 2013, 23, 1051 – 1055.

  7. Powell, N. A. et al. Bioorg. Med. Chem. Lett. 2013, 23, 1051 – 1055.

  8. PK profil vybraných analógov (potkan) Powell, N. A. et al. Bioorg. Med. Chem. Lett. 2013, 23, 1051 – 1055.

  9. Powell, N. A. et al. Bioorg. Med. Chem. Lett. 2013, 23, 1051 – 1055.

  10. Powell, N. A. et al. Bioorg. Med. Chem. Lett. 2013, 23, 1051 – 1055.

  11. Mapa kinázovej aktivity vybraných analógov Powell, N. A. et al. Bioorg. Med. Chem. Lett. 2013, 23, 1051 – 1055.

  12. Záver

  13. Ďakujem vám za pozornosť

  14. Dofetilid www.en.wikipedia.org

  15. CYP2D6 www.en.wikipedia.org

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