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Erythroid maturation

Erythroid maturation. Proerythroblast. Basophilic erythroblast. Polychromatophilic erythroblast. Acidophilic erythroblast. Reticulocyte. Mature RBC. Erythroid Dysplasia. Myeloid maturation.

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Erythroid maturation

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  1. Erythroid maturation

  2. Proerythroblast

  3. Basophilic erythroblast

  4. Polychromatophilic erythroblast

  5. Acidophilic erythroblast

  6. Reticulocyte

  7. Mature RBC

  8. Erythroid Dysplasia

  9. Myeloid maturation Myeloblast Promyelocyte Myelocyte Metamyelocyte Band Neutrophil

  10. Myeloblast

  11. Promyelocyte

  12. Myelocyte

  13. Metamyelocyte

  14. Mature neutrophil

  15. ? ? ? ? ?

  16. Megakaryoblas

  17. Plasma cell

  18. leukemia

  19. Leukemia A disorder characterised by the accumulation of malignant white cells in the BM and PB. • Acute leukemia • Chronic leukemia

  20. Acute leukemia A malignant disorder in which blasts constitute >20% of the BM cells Classification: • Acute Myeloid Leukaemia (AML) • Acute Lymphoblastic Leukaemia (ALL)

  21. Acute myeloblastic leukemia ( M0, M1, M2 ) Acute promyelocytic leukemia ( M3, M3v ) Acute myelomonocytic leukemia ( M4, M4Eo ) Acute monocytic leukemia ( M5a, M5b ) Acute erythroleukemia ( M6 ) Acute megakaryocytic leukemia ( M7 ) AML FAB classification

  22. Distinguishing AML from ALL • Light microscopy • AML: Auer rods, cytoplasmic granules • ALL: no Auer rods or granules. • Flow cytometry • Special stains (cytochemistry)

  23. Cytochemistry AML • Myeloblastic - SBB, MPO, Chloroacetate Esterase • Monoblastic - Non Specific Esterase ALL • B lineage – PAS • T lineage – Acid Phosphatase

  24. AML-M0

  25. AML-M1

  26. AML-M1

  27. AML-M1 (MPO)

  28. AML-M2

  29. AML-M2 (MPO)

  30. AML-M3

  31. AML-M3 (MPO)

  32. AML-M4E0

  33. AML-M5a

  34. AML-M5b

  35. AML-M5aCytochemistry NBE

  36. AML-M6

  37. AML-M6

  38. AML-M7

  39. AML-M7(Dirty Field)

  40. AML-M7Cytochemistry MPO

  41. AML-M7 (PAS)

  42. CML

  43. ALL-L1

  44. ALL-L2

  45. ALL-L3

  46. CLL

  47. PLL

  48. HCL

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