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Glycolysis 1

Glycolysis 1. Lecture 22 Pages 427-439. With or without O2. Early Earth had no oxygen Just a form of glycolysis existed before that time. 13_01_stepwise_oxidat.jpg. ATP & Heat. Three key food types - sugars, fats, & proteins Three stage breakdown -

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Glycolysis 1

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  1. Glycolysis 1 Lecture 22 Pages 427-439

  2. With or without O2 • Early Earth had no oxygen • Just a form of glycolysis existed before that time

  3. 13_01_stepwise_oxidat.jpg

  4. ATP & Heat • Three key food types - sugars, fats, & proteins • Three stage breakdown - • Digestion - reduces large polymers to subunits - sugars, fatty acids & glycerol, and amino acids • outside cells - gut • inside cells in lysozymes • Oxidative Breakdown GLYCOLYSIS - cytosol and mitrochondria • Complete oxidation - within mitrochondria

  5. 13_02_cell_metabolism.jpg

  6. GLYCOLYSIS - No oxygen needed for this 10 step phase Net result is the formation of just two ATP molecules & also two molecules of NADH 13_03_glycolysis.jpg A typical cell has about a billion ATP molecules at one time. These are used and regenerated with a minute or two!

  7. Without Oxygen…

  8. FERMENTATION - Without oxygen - there is really only fermentation. Two main types - Generation of lactate - as in muscle cels running without oxygen. The lactate is excreted from the cell…

  9. The alternative, as seen here, is the formation of ethanol. Both take place in the cytosol.

  10. 13_05_01_6_7_glycolysis.jpg

  11. 13_05_02_6_7_glycolysis.jpg

  12. 13_06_NADH _ATP .jpg

  13. With Oxygen… • The pyruvate generated by glycolysis is rapidly degraded to yield lots of energy and CO2 • Oxygen is eventually needed for the process to continue • CITRIC ACID CYCLE

  14. 13_08_acetylCoA_CO2.jpg

  15. 13_09_01_fatty_acids_oxd.jpg

  16. 13_09_02_fatty_acids_oxd.jpg

  17. 13_10_acetylCoA_prod.jpg

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