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Prevention trials pipeline

Vaccines - Adenovirus-1 Adenovirus-2. Microbicides – CS-1 CS-2 Carraguard. HSV-2 Treatment - Infectiousness. Community VCT and HIV Support. Male Circumcision - Susceptibility. Vaccines - Prime/Boost. Female Barrier- Diaphragm. Oral PrEP - IDU. Microbicides BG/Pro2000 Pro2000

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Prevention trials pipeline

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  1. Vaccines - Adenovirus-1 Adenovirus-2 Microbicides – CS-1 CS-2 Carraguard HSV-2 Treatment - Infectiousness Community VCT and HIV Support Male Circumcision - Susceptibility Vaccines - Prime/Boost Female Barrier- Diaphragm Oral PrEP - IDU • Microbicides • BG/Pro2000 • Pro2000 • TDF Male Circumcision - Infectiousness HSV-2 Treatment – Susceptibility • Oral PrEP • MSM • Heterosexual Index Partner Treatment Oral PrEP - West Africa Prevention trials pipeline 2012 2010 2006 2008 2009 2007 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s View

  2. Research must have a potential benefit. Research examines a question to which the answer is unknown. Research must be able to answer the question or contribute meaningful information. Good research must be unbiased. Research is not the same as health care Research Principles

  3. Decision-making about research Data Monitors

  4. test product is definitely effective; Data Monitors can stop trial if evidence that

  5. test product may be causing harm Data Monitors can stop trial if evidence that

  6. that it is futile -- trial can no longer answer the assigned question Data Monitors can stop trial if evidence

  7. PrEP 2004 --Political controversy can stop trials r

  8. Managing fall out of CS resultsNegative press erupts in South Africa

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