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MS Lesion Visualization Assisted Segmentation

MS Lesion Visualization Assisted Segmentation. Daniel Biediger. COSC 6397 – Scientific Visualization. Multiple Sclerosis. Autoimmune disease of the central nervous system Affects 2.5 million people globally, ~100 per 100,000 Damage to the insulating myelin sheaths around brain cells

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MS Lesion Visualization Assisted Segmentation

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  1. MS Lesion Visualization Assisted Segmentation Daniel Biediger COSC 6397 – Scientific Visualization

  2. Multiple Sclerosis • Autoimmune disease of the central nervous system • Affects 2.5 million people globally, ~100 per 100,000 • Damage to the insulating myelin sheaths around brain cells • Appears as a range of cognitive and physical disability • Progresses at different rates with remission and relapse Myelin: ~40% water, ~40-50% lipids

  3. Multiple Sclerosis • Identified in-vivo with MRI images • Normally 3 tissues: GM, WM, CSF (SG, SB, LCR) • Lesion appear hyper- or hypo-intense (bright or dark) • Reflects a difference in relaxation times for lipids/water • Detected as an outlier to the normal WM • FLAIR MRI (Fluid Attenuated Inversion Recovery) best

  4. MS Detection Challenges • WM Lesion detection is a challenge • Overlap in intensity between tissue classes • 3D brain structure (sulcus, ventricles, multiple tissues) • Partial Volume Effects (PVE) • Artifacts from fluid/patient motion, tumors, etc • Random noise, bias field, sun spots, etc • Requires an expert to identify lesions • Tissue identification (T1-weighted MRI) • Lesion detection (FLAIR MRI) • Time consuming, difficult (multi-modality), and subjective

  5. MS Lesion Appearance in Flair This? Is this? or This? or This?

  6. Result Comparison FLAIR MRI Base Method Expert Me Under Segmentation Correct Segmentation Over Segmentation Results DICE = 0.65

  7. Project Timeline

  8. Questions ?

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