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Modeling Glucose-Insulin Relationship

Outline. What is diabetes?Traditional methods of treatmentModel transfer function for glucose-insulin relationshipMatlab and Simulink simulationsCurrent state of pseudo-pancreasConclusion. What is Diabetes?. Type 1 DiabetesAlso known as Juvenile Diabetes5-10% of all Diabetes casesType 2 Diab

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Modeling Glucose-Insulin Relationship

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    1. Modeling Glucose-Insulin Relationship Jeremy Heersink December 6, 2002 ENGR 315 Prof. Ribeiro

    2. Outline What is diabetes? Traditional methods of treatment Model transfer function for glucose-insulin relationship Matlab and Simulink simulations Current state of pseudo-pancreas Conclusion

    3. What is Diabetes? Type 1 Diabetes Also known as Juvenile Diabetes 5-10% of all Diabetes cases Type 2 Diabetes Generally Age, Obesity, or Family Related Glucose Insulin

    4. Traditional Methods of Treatment Diet Physical Activity Home blood glucose testing Requires a finger prick for blood Daily Insulin Shots Sometimes 2-3 times per day.

    5. Newer Technologies for Treatment Pancreas Transplantation Insulin Pump Pager sized device with tube into body Still Human controlled Pseudo Pancreas Fully Automated system with a outer supply of insulin Stem Cell injection Tested in Rats

    6. Healthy Response to Glucose Body receives glucose into bloodstream via eating. Body sees the glucose, which causes an increase in Calcium ions. The Calcium ions then trigger the insulin release to break down glucose into useful items, and no longer damage body.

    7. Modeling Glucose-Insulin Relationship Insulin release at the molecular level: metabolic-electrophysiological modeling of the pancreatic beta-cells. Written by Michele Giugliano, Marco Bove, and Massimo Grattarola. Downloaded from a Applied Sciences Online Research Database Accepted for publications on IEEE Biomedical Engineering.

    8. Equations for Simulations

    9. Transfer Function Glucose in, Insulin Out: Insulin In, Glucose Out:

    10. Matlab and Simulink Simulations

    11. Simulink Simulations Cont.

    12. Pseudo-pancreas Attempts to use something similar (but more complex) to what I showed to monitor and provide correct amount of Insulin Technology is less than 3 years old. Control System tools can be used to model and develop this system.

    13. Conclusion Diabetes is a disease that can be quite devastating Steps are being made to control this disease Biology papers aren’t much fun to read. Control Systems used in a humankind helping capacity Pseudo-pancreas is a helpful invention for many who suffer from diabetes.

    14. Questions?

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