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MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B.

MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer. AIMS:

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MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B.

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  1. MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA PROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer AIMS: Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; Training in post-genomics and technological dissemination.

  2. MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA PROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer AIMS: Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; Training in post-genomics and technological dissemination.

  3. MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA PROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer AIMS: Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; Training in post-genomics and technological dissemination.

  4. MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA PROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer AIMS: Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; Training in post-genomics and technological dissemination.

  5. Work Packages breakdown: • Workpackage 4 • Activity 1-5:Cellular models • Coordination:Second Univ. Napoli • Workpackage 2 • Activity 1-4:Proteomics • Coordination:ISA-Natl Res. Council • Workpackage 3 • Activity 1:Animal models • Coordination:Univ. Milano • Workpackage 4 • Activity 1-3:Tumor profiling and clinical studies • Coordination:Univ. Torino • Workpackage 5 • Activity 1-4:Bioiformatics • Coordination:Second Univ. Napoli Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer

  6. MOLECULAR PROFILING FUNCTIONAL CHARACTERIZATION VALIDATION functional genomic and proteomic analyses in experimental models gene expression profiling of tumor samples ‘in situ’ analyses (tissue arrays and LCM) Clinical data (hormone responsiveness) Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer

  7. MOLECULAR PROFILING FUNCTIONAL CHARACTERIZATION VALIDATION UniNa2 IRCC-To UniTo IEO-Mi UniFe IDI-Rm UniMi (in vivo) IST-Ge(in vivo) ISA-CNR(proteomics) UniFe IRCC-To UniNa2 UniFe IRCC-To IRCC-To UniFe UniNa2 ISA-CNR(proteomics) functional genomic and proteomic analyses in experimental models gene expression profiling of tumor samples ‘in situ’ analyses (tissue arrays and LCM) clinical studies BIOINFORMATICS UniNa2 ISA-CNR IST-Ge IEO-Mi UniTo IRCC-To CINECA-Bo UniFe Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer

  8. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer http://www.hrbc-genomics.net/ Alessandro Weisz Dipartimento di Patologia generale Seconda Università degli Studi di Napoli alessandro.weisz@unina2.it

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