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Introduction

MK-5172, a Second Generation HCV NS3/4A Protease Inhibitor is Active Against Common Resistance Associated Variants (RAVs) and Exhibits Cross-Genotype Activity. Introduction. Aim/Methods. Potency of MK-5172 and telaprevir against known telaprevir RAVs.

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Introduction

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  1. MK-5172, a Second Generation HCV NS3/4A Protease Inhibitor is Active Against Common Resistance Associated Variants (RAVs) and Exhibits Cross-Genotype Activity

  2. Introduction

  3. Aim/Methods

  4. Potency of MK-5172 and telaprevir against known telaprevir RAVs

  5. Pan-genotypic Activity of MK-5172 in a Cell-Based HCV Protease Assay

  6. MK-5172 Activity against HCV Proteases Isolated from Early Gen HCV Proteases : Patient 2: Gt1A

  7. MK-5172 Activity against HCV Proteases Isolated from Early Gen HCV Proteases : Patient 2: Gt1A

  8. Summary

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