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بسم الله الرحمن الرحيم. Cardiovascular system and exercise. Circulatory changes during muscular exercise: blood flow for resting muscles (600-900ml/min.). during exercise 1200 - 20000 ml/min. Mechanisms of increase muscle blood flow:
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Circulatory changes during muscular exercise: • blood flow for resting muscles (600-900ml/min.). • during exercise 1200 - 20000 ml/min. Mechanisms of increase muscle blood flow: • increases metabolites (H+, Co2,K, kinins ete …) • rise of temperature. • excitement and sympathetic activity. • adrenalin secretion. • hypoxia. (nitric oxide).
The effect of muscular exercise on the C.V.S. either generalor local effects: A- general effects. I- increase heart rat 70 - 140-180 B\min. by: • impulses from higher centers (C.C., respiratory center and hypothalamus) • rise of body temperature. • chemical changes (H+, PCO2, PO2). • increases venous return. • impulse from contracting muscle.
II- increases venous return about 5-6 folds. By: • arteriolar dilatation • muscle contraction “peripheral hearts” • respiratory pump. • increases of venomotor • contraction of blood reservoirs.
III- cardiac output: Increase from 5L/min 25 or 35 L/min. C.O.P= heart rate x stork volume (V.R).
IV- Blood pressure: A.BL.P= C.O.P x peripheral resistance. • increases in C.O.P increases the systolic blood pressure. • fall in peripheral resistance (by V .D. of exercising muscle) lower the diastolic Bl.P or may remain unchanged.
B) Local effects: I- local blood flow to much increase by arteriolar and capillary dilation. II- tissue fluid and lymph. To much increases due to capillary dilatation.
Regional distribution of blood flow in different body systems during exercise