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BIBC 102 Summer 2005 Lecture 4 August 8, 2005

BIBC 102 Summer 2005 Lecture 4 August 8, 2005. Fig. 13.9. FORMATION OF ATP IN LIVING CELLS. 1. Glycolysis 2. Oxidative phosphorylation in mitochondria 3. Oxidative phosphorylation in chloroplasts. BIOLOGICAL WORK. 1. Activation of metabolism

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BIBC 102 Summer 2005 Lecture 4 August 8, 2005

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  1. BIBC 102 Summer 2005 Lecture 4 August 8, 2005

  2. Fig. 13.9

  3. FORMATION OF ATP IN LIVING CELLS 1. Glycolysis 2. Oxidative phosphorylation in mitochondria 3. Oxidative phosphorylation in chloroplasts

  4. BIOLOGICAL WORK 1. Activation of metabolism 2. Transport of metabolites in and out of cells 3. Biosynthesis of macromolecules: DNA, RNA, protein, polysaccharides 4. electrical signaling (nerve cells) 5. Motility and force generation 6. Regulatory mechanisms

  5. Chapter 15 in Lehninger Glycolysis Catabolism of Hexoses

  6. V&V 16.5

  7. acid-base catalysis in the isomerase reaction

  8. V&V 16.6

  9. formation of a Schiff base as a covalent intermediate in the aldolase reaction

  10. V&V 16.9

  11. V&V 16.10

  12. LNC 15.7

  13. H2O H2O Hydrolysis ? LNC 15.8

  14. THIAMINE PYROPHOSPHATE V&V 16.28

  15. Metabolic flux and its control

  16. LNC 15.16

  17. Phosphofructokinase 1 regulatory site active site active site regulatory site (only two of four subunits shown) LNC 15.18a

  18. Other sugars • Fructose • Galactose • Mannose pp. 534-537 (Section 14.2) Feeder Pathways for Glycolysis

  19. Other Common Sugars Monosaccharides: fructose galactose mannose Disaccharides: sucrose Glu-Fru lactose Gal-Glu maltose Glu-Glu trehalose Glu-Glu

  20. Fig. 9.12 in LNC

  21. Disaccharides Galactose Glucose Figure 7-12

  22. Glucose Fructose Figure 7-12

  23. Glucose Glucose Figure 7-12

  24. LNC 15.11

  25. Lactose + H2O D-galactose + D-glucoseSucrose + H2O D-fructose + D-glucoseTrehalose + H2O 2 D-glucose Enzymes on surface of intestinal epithelial cells Lactase Sucrase Trehalase p. 535

  26. Lactose IntoleranceOMIMOnline Mendelian Inheritance in Man

  27. Galactose to Glucose 1-P Figure 14-11

  28. Figure 14-11

  29. p. 565

  30. Figure 14-11

  31. NADH + H+ NAD+ Figure 14-11, p. 537

  32. Enzymes required for galactose metabolism kinase Galactose Galactose 1-P UDP-Glu ATP ADP Uridyl transferase epimerase UDP-Gal Glucose 1-P phosphoglucomutase Glucose 6-P

  33. GLYCOGEN METABOLISM LNC Chapter 15 GLYCOGEN SYNTHESIS LNC Chapter 20

  34. Chapter 15 pp. 560-570(some figures from Chapter 7) in Lehninger 4th ed. Glycogen Metabolism

  35. Catabolic PathwaysGlycogen → Glu-6-P (glycogenolysis)Glu-6-P → Pyruvate (glycolysis)Anabolic PathwaysPyruvate → Glu (gluconeogenesis)Glu → Glycogen (glycogenesis)

  36. Figure 7-14b

  37. 3 enzymes of glycogen breakdown(Glycogenolysis) • glycogen phosphorylase • glycogen debranching enzyme • phosphoglucomutase

  38. End of lecture 4, August 8, 2005

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