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** ** *** ** *** ** Figure S2. Novel Hoxa9/ Meis1 binding regions show enhancer activity in luciferase assays. Twenty-two novel Hoxa9/ Meis1 binding regions of ~1,000 bp in length were cloned into pTAL-luc luciferase reporter and electroporated into K-562 cells. Enhancer activity of the Hoxa9/ Meis1 binding regions was compared to a known Runx1 conserved noncoding element(Runx1_chr16(+23)) and two control regions randomly selected in the genome as a negative control. Data is presented as the Mean +/- SD in triplicate normalized to pTAL-luc. ([*] P > 0.05; [**] P < 0.05; [***] P < 0.001) P values determined using Standard t test.