1 / 4

B. Winblad and N. Poritis International Journal of Geriatric Psychiatry 1999, 14: 135-146

Memantine in Severe Dementia: Results of the M-Best Study Benefit and Efficacy in Severely Demented Patients During Treatment With Memantine. B. Winblad and N. Poritis International Journal of Geriatric Psychiatry 1999, 14: 135-146 . Study Design. No. of patients N = 166 (nursing home)

leda
Download Presentation

B. Winblad and N. Poritis International Journal of Geriatric Psychiatry 1999, 14: 135-146

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Memantine in Severe Dementia: Results of the M-Best StudyBenefit and Efficacy in Severely Demented Patients During Treatment With Memantine B. Winblad and N. Poritis International Journal of Geriatric Psychiatry 1999, 14: 135-146

  2. Study Design No. of patients N = 166 (nursing home) Design Double-blind, randomized, placebo- controlled, multicenter study Diagnosis Primary dementia (AD, VaD, mixed types) Age 60 – 80 years (mean 68.4) Severity MMSE < 10 (mean 6.3), GDS 5 – 7 Dose; duration 10 mg memantine/day; 12 weeks Primary efficacy Global: CGI-C parameters Care Dependence: BGP subscore Secondary efficacy Function/Behavior: D-Scale, BGPparameter Winblad and Poritis., Int J Geriat Psychiatr 1999

  3. 80 70 60 50 40 30 20 10 0 ** 73% * 59% 45% 40% Memantine Placebo Memantine Placebo Week 4 Week 12 Memantine Improves Global Impression (CGI-C) ITT analysis, N = 166 Response = improvement Responders [%] in CGI-C *p = 0.006, ** p = 0.001 versus placebo Winblad and Poritis., Int J Geriat Psychiatr 1999

  4. Summary • Memantine is efficacious in severely demented patients suffering from probable Alzheimer’s disease or probable vascular dementia • Functional improvement was significant in memantine- treated patients • Tolerability of memantine was good Winblad and Poritis., Int J Geriat Psychiatr 1999

More Related