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Klinefelter Syndrome. Joseph Tang ET 11B AP Biology. Causes. nondisjunction in meiosis extra X chromosome(s) gamete has >1 sex chromosome zygote has >2 sex chromosomes XXY/XXXY/XXYY etc. Symptoms. breasts o.o lack of body hair lack of testosterone lower physical ability. Diagnosis.
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Klinefelter Syndrome Joseph Tang ET 11B AP Biology
Causes nondisjunction in meiosis extra X chromosome(s) gamete has >1 sex chromosome zygote has >2 sex chromosomes XXY/XXXY/XXYY etc.
Symptoms breasts o.o lack of body hair lack of testosterone lower physical ability
Diagnosis aspermatogenesis karyotype: blood sample WBCs separated chromosomal abnormalities (e.g. X chromosome)
Prognosis emotional problems/social pressure decreased life expectancy (not definitive) disease (osteoporosis, breast cancer etc.)
Treatment irreversible (genetic) psychosocial support cosmetic surgery to remove breasts
History Harry Klinefelter (1942): reports about men with large breasts and little body hair 1950s: research on more symptoms 1970s: studies on newborns confirm disease