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Institut for Regional Sundhedsforskning

Institut for Regional Sundhedsforskning. Det Sundhedsvidenskabelige Fakultet Syddansk Universitet. Faculty of Health Sciences. Odense University Hospital. KLIN OUH. IRS Center. IRS Center. IRS Center. IRS Center. IRS ansatte. IRS ansatte. K. K. K. K. K. K. K.

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Institut for Regional Sundhedsforskning

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  1. Institut for Regional Sundhedsforskning Det Sundhedsvidenskabelige Fakultet Syddansk Universitet

  2. Faculty of Health Sciences Odense University Hospital

  3. KLIN OUH IRS Center IRS Center IRS Center IRS Center IRS ansatte IRS ansatte K K K K K K K The Southern Danish region

  4. Forskning • Klinisk forskning • Translationel forskning • Grundforskning • Kommunikation og patienttilfredshed

  5. Fokuserede forskergrupper • Center Sygehus Lillebælt • Molekylær ældningsforskning, Steen Kølvraa • Syddansk colorectal cancer gruppe, Anders Jakobsen • Klinisk cellebiologi, Jean-Marie Delaisse • Urologisk forskningsgruppe, Palle Osther • Rygcenter Syddanmark, Claus Manniche • Forskningsenhed for Sundhedstjenesteforskning, Jette Ammenthorp

  6. Fokuserede forskergrupper • Center Sydvestjylland • Forskningsinititativ for FAM forskning • Center Sønderjylland • Reumatologisk forskning, Kim Hørslev-Petersen • Neurologisk forskningsgruppe, Egon Stenager • Center OUH-Svendborg Sygehus • Preventiv kardiologi, Kenneth Egstrup

  7. Formål • At facilitere klinisk forskning på OUH Virkemidler • Gøre det lettere at opbygge biobanker • Gøre det lettere at opbygge kliniske databaser • Facilitere registerforskning på kohorter • Skabe åbenhed om data og dermed facilitere videnskabeligt samarbejde

  8. Strategi • Baseres på eksisterende forsknings-infrastrukturer • Biobanker: • Klinisk biokemisk afd. • Klinisk patologisk afd. • Klinisk immunologisk afd. • Databasen: • Det danske tvillingeregister • Faciliteres af fælles IT-portal med stor brugervenlighed

  9. SAMESleep, work and metabolism A collaboration between SDU, CAU and UKSH

  10. Circadian rhythms circa24-hour-rhythms circadian clock time

  11. Circadian rhythms Blood pressure Plasma glucose Temperature Cortisol

  12. Circadian rhythmsaregenerated in the human bodybybiologicalclocks Central clock in the brain Peripheral clocks in the body SCN

  13. The endogenousrhythmsaregeneratedbyclockgenes Cryptochrome Period Timeless Clock Arntl

  14. The endogenousclocksareadjustedtothe 24-hour-rhythm byexternalfactors Environment Biological clock

  15. External factors • Light-dark-cycle • Time of food intake • Time of physical activity • Social time cues

  16. Background • A large proportion of the Danish and German population suffers from metabolic disorders, sleep disturbances and shift work problems. • Sleep quality and diurnal rhytm are associated with obesity and probably also hypertension and diabetes • Metabolic and sleep disturbances are an important factor for invalidity resulting in early retirement of workers and high costs for the health system.

  17. Aims • To carry out a twin study of sleep, nutrition and metabolism and analyze the collected data for associations and interactions between these phenotypes • To determine the interaction of sleep, nutritional and working patterns as well as metabolic disorders with human circadian rhythms, based on genetic and hormonal data. • To analyse whether different sleep and working patterns affect the expression of genes

  18. Mobilt undersøgelsescenter Status: 550 /1512 pers. Spørgeskemaer! F-glucose og insulin, lipider Hormoner af betydning for vægt Højde, vægt, hip, waist Bioimpedance (body age) EKG, lungefunktion DNA, RNA, spyt, urin

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