1 / 28

#16 - R Siliciano: Das „Instanteous Inhibitory Potential“ IIP

#16 - R Siliciano: Das „Instanteous Inhibitory Potential“ IIP.

leland
Download Presentation

#16 - R Siliciano: Das „Instanteous Inhibitory Potential“ IIP

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. #16 - R Siliciano: Das „Instanteous Inhibitory Potential“ IIP • Ein schon auf der Mexico-Konferenz vorgestelltes, jetzt erweitertes hypothetisches Modell zur Abschätzung der virologischen Potenz von Einzelsubstanzen und –Kombinationen aus deren pharmakokinetischen und pharmakologischen Eigenschaften • Grundhypothese – und ein neues Paradigma – ist die Annahme, dass die geringe residuale Virämie unter HAART (1.) aus stabilen Reservoiren stammt, (2.) dort keine oder wenig virale Evolution stattfindet und (3.) diese Virämie ohne wesentliche Bedeutung für den langfristigen Erfolg der Therapie ist.

  2. Forecasting by Viral dynamicsMission still not completed, need for new models #16 - R Siliciano, 16th CROI 2009, Montreal

  3. Forecasting by Viral dynamicsMission still not completed, need for new models #16 - R Siliciano, 16th CROI 2009, Montreal

  4. Forecasting by Viral dynamicsMission still not completed, need for new models #16 - R Siliciano, 16th CROI 2009, Montreal

  5. Forecasting by Viral dynamicsMission still not completed, need for new models Prevalence of latently infected CD4+ T cells ~ 1 : 1.000.000 #16 - R Siliciano, 16th CROI 2009, Montreal

  6. Forecasting by Viral dynamicsMission still not completed, need for new models Prevalence of latently infected CD4+ T cells ~ 1 : 1.000.000 #16 - R Siliciano, 16th CROI 2009, Montreal

  7. Residuale Virämie unter HAART „Blip“ #16 - R Siliciano, 16th CROI 2009, Montreal

  8. Ongoing cycles of continuing replication from latent infected cells  no (or little) viral evolution (of resistance)  not influenced by intensification of HAART Residuale Virämie unter HAART #16 - R Siliciano, 16th CROI 2009, Montreal

  9. Über lange Zeit kaum virale Evolution:Indiz für Replikation aus stabilen Reservoiren #16 - R Siliciano, 16th CROI 2009, Montreal

  10. Modellrechnung / HypothesePro Replikationszyklus werden ~1 Mio. Zellen infiziert  Answer: ~ 6 log #16 - R Siliciano, 16th CROI 2009, Montreal

  11. Oligoklonale Replikation undwenig virale Evolution unter HAART #16 - R Siliciano, 16th CROI 2009, Montreal

  12. Oligoklonale Replikation undwenig virale Evolution unter HAART #16 - R Siliciano, 16th CROI 2009, Montreal

  13. Was sagt die IC50 aus?… oder: warum man den IIQ braucht #16 - R Siliciano, 16th CROI 2009, Montreal

  14. Lineare Darstellung und IC50 #16 - R Siliciano, 16th CROI 2009, Montreal

  15. Logarithmische Darstellung und IIP #16 - R Siliciano, 16th CROI 2009, Montreal

  16. Instanteous Inhibitory Potential (IIP) #16 - R Siliciano, 16th CROI 2009, Montreal

  17. Variationen des IIP – mögliche Bedeutung für die Resistenzbarriere #16 - R Siliciano, 16th CROI 2009, Montreal

  18. Proof of concept:Übertragung auf klinische Studien #16 - R Siliciano, 16th CROI 2009, Montreal

  19. Vorhersage von „Forgivingness“ und antiviraler „Potenz“ #16 - R Siliciano, 16th CROI 2009, Montreal

  20. Forecasting by Viral dynamicsMission still not completed, need for new models #16 - R Siliciano, 16th CROI 2009, Montreal

  21. Wo liegen die IIPs der Einzelsubstanzen? #16 - R Siliciano, 16th CROI 2009, Montreal

  22. … und wo die IIPs von Kombinationen? #16 - R Siliciano, 16th CROI 2009, Montreal

  23. Forecasting by Viral dynamicsMission still not completed, need for new models #16 - R Siliciano, 16th CROI 2009, Montreal

  24. … und wo bei Resistenzen?Rückgang der IIPs ist „ableitbar“ #16 - R Siliciano, 16th CROI 2009, Montreal

  25. … Kombinationsauswahl nach „IIP-Summe“ #16 - R Siliciano, 16th CROI 2009, Montreal

  26. Warum führt die Gabe von Raltegravir (vs. EFV) zu einem schnelleren Abfall der VL aber die low-level Replikation bleibt unbeeinflusst? #16 - R Siliciano, 16th CROI 2009, Montreal

  27. Forecasting by Viral dynamicsMission still not completed, need for new models #16 - R Siliciano, 16th CROI 2009, Montreal

  28. Forecasting by Viral dynamicsMission still not completed, need for new models #16 - R Siliciano, 16th CROI 2009, Montreal

More Related