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Meeren et al The Journal of Neuroscience, February 15, 2002, 22(4):. A. first 500 msec. Hindpaw. SmI. Thalamus. 2.9. 11.7. 30.0. 6.1. UpperLip Nose. 8.1. 4.3. “FOCUS”. VPL. VPM. B. whole seizure. Hindpaw. SmI. Thalamus. 4.9. 29.3. 9.9. UpperLip Nose. 18.4. 3.1.
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Meeren et al The Journal of Neuroscience, February 15, 2002, 22(4):
A. first 500 msec Hindpaw SmI Thalamus 2.9 11.7 30.0 6.1 UpperLip Nose 8.1 4.3 “FOCUS” VPL VPM B. whole seizure Hindpaw SmI Thalamus 4.9 29.3 9.9 UpperLip Nose 18.4 3.1 8.8 “FOCUS” VPL VPM Association (%) 70-80 60-70 50-60 40-50 30-40 20-30 Evolution of absence seizures: a summary Cortico-Cortical. Intra-Thalamic and Cortico-Thalamic relations Focus does not mean a “point source”, just that the local neuronal population has a lower threshold for initiating seizures. During the seizures it becomes just a part of the oscillating network.. The oscillations constitute an emergent property of the whole system. Meeren, Pijn, van Luijtelaar, Coenen and Lopes da Silva, J. Neurosci 2002,22:1480-95
Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsy Ayten A Gurbanova,1Rezzan Aker,1Kemal Berkman,1FilizYilmaz Onat,1Clementana M van Rijn,2 and Gilles van Luijtelaar2* • Br J Pharmacol. 2006 August; 148(8): 1076–1082.
4th International Workshop onSeizurePredictionKansas City, Missouri – June 4 -7, 2009 Ictogenesis: Focus or Network? Fernando Lopes da Silva Center of Neuroscience Swammerdam Institute for Life Sciences University of Amsterdam
Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats H. K. M. Meeren, J. P. M. Pijn†, E. L. J. M. Van Luijtelaar, A. M. L. Coenen, and F. H. Lopes da Silva, The Journal of Neuroscience, February 15, 2002
Ayten A Gurbanova, Rezzan Aker, KemalBerkman, FilizYilmazOnat, Clementana M van Rijn, and Gilles van Luijtelaar. Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsy. Br J Pharmacol. 2006 August; 148(8): 1076–1082.