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Epigenetic Status of GDNF in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

Study Aim. clarify the molecular mechanisms underlying the susceptibility and adaptation to chronic stress using stress-vulnerable BALB and stress-resilient B6 mice strains.". Study Organisms. Inbred BALB/c (BALB) mice bred to be really high strung. stress-vulnerableC57BL/6 (B6) mice bred

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Epigenetic Status of GDNF in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

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    1. Epigenetic Status of GDNF in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

    2. Study Aim “…clarify the molecular mechanisms underlying the susceptibility and adaptation to chronic stress using stress-vulnerable BALB and stress-resilient B6 mice strains.”

    3. Study Organisms Inbred BALB/c (BALB) mice – bred to be really high strung. stress-vulnerable C57BL/6 (B6) mice – bred to be really laid back Stress-resistant

    4. How do you measure stress in mice? Forced Swim Test Measure time to as well as length of immobility Sucrose Preference Test Measure preference for sucrose water or water Social Interaction Test Measure amount of social interaction Novelty-suppressed Feeding Test Measure amount of time it takes to eat in a novel environment Elevated Zero Maze Test Measure time spent in open sections.

    5. Can you tell which one is a maze? Apparently neither can neuroscientists.

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