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Project Overview. Goal is to support NeSSI
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1. Utilizing NeSSI for Analytical Applications Brian Marquardt
Dave Veltkamp
Center for Process Analytical Chemistry (CPAC)
University of Washington, Seattle, WA
2. Project Overview Goal is to support NeSSI related development within CPAC
Developing infrastructure and platforms
Developing sensors and applications
Promote and support wider NeSSI adoption and use
Web based support
Interaction with NeSSI community
3. What does NeSSI Provide Simple Lego®-like assembly (v)
Easy to re-configure
No special tools or skills required
Overall lower cost of build reduce time to configure/install by 75%
Improved reliability
Lower cost of ownership reduce total cost by 40%
Standardized flow components (v)
Mix-and-match compatibility between vendors
Growing list of components
Standardized electrical and communication (+)
Plug-and-play integration of multiple devices
Simplified interface for programmatic I/O and control
Advanced analytics (+)
Micro-analyzers
Integrated analysis or smart systems
4. The NeSSI rail Concept Enabler for Micro Analytical
Opportunities exist to exploit NeSSI standards in other laboratory applications It is really about creating a set of standard interfaces, so current and new analytical devices and sample system components can be quickly and easily integrated into the process environment.
A standard electrical interface that will provide power, a standard communication format, and standard protocol between these devices.
A standard software package that will allow for inter device communication, control, and diagnostics at the installation level. And a standardized portal and protocol for communication with the plant DCS or Enterprise Management System.
A standard mechanical interface. A standardized footprint for interfacing these devices and components with the process sample. It is really about creating a set of standard interfaces, so current and new analytical devices and sample system components can be quickly and easily integrated into the process environment.
A standard electrical interface that will provide power, a standard communication format, and standard protocol between these devices.
A standard software package that will allow for inter device communication, control, and diagnostics at the installation level. And a standardized portal and protocol for communication with the plant DCS or Enterprise Management System.
A standard mechanical interface. A standardized footprint for interfacing these devices and components with the process sample.
5. NeSSI Sensing Technologies Chromatography
Thermal Desorption (?)
GC (+)
LC (chip based) (+)
SEC, IC (?)
Dielectric (v)
Spectroscopies
IR (+), NIR (+)
UV- Vis (+)
Raman (v)
Fluorescence (+)
Refractive Index (v) Vapochromic Sensors (+)
GLRS (+)
Particle Sizing
Light scattering (?)
Conductivity (v)
Turbidity (+)
pH (v)
SPR (+)
Mass Spectrometry (v)
Impedance (+)
Terrahertz (?), NMR (?)
6. Where Does NeSSI Fit in the Lab Instrument/Sensor Interfaces
Design standards make development simpler
Simplified design, construction, and reconfiguration
Reduced sample variability to account for
Calibration/validation built-in
Consistent physical environment for measurement
Stream switching and/or mixing allow generation of standards to match analytical requirements
Bridge to micro analytical developments
Reaction monitoring
Microreactors and continuous flow reactors
Batch reactors (with fast loop)
Sample Preparation
Gas handling (mixing, generation, delivery)
Liquid handling (mixing, dilution, conditioning, etc.)
7. Agilent NeSSI Dielectric Sensor
8. Vapochromic Sensor Interface Optical sensor based on vapochromatic compounds
Responds to different analytes by intensity and wavelength shifts in fluorescence signal
Optical detection using simple spectrometer
LED excitation light source
Simple reflectance 2 fiber optical measurement
Use of BallProbe to provide single-sided optical interface
Vapochrome coated on ball surface
Inserted into standard NeSSI tube fitting block
NeSSI system provides controlled delivery and mixing of gas streams to sensor
9. NeSSI Gas Mixing System Using a customized Ballprobe reflectance probe for vapochromic detection
10. Vapochromic O2 Sensor Response
11. New Gas Sensor Testing System More capability to generate analytical vapors, gas blending, and on-line dilution of vapor streams for method development work
Vapor generation initially off-system research opportunity for integrating onto NeSSI platform
Serial dilution possibilities allows wide concentration range to be investigated
12. NeSSI Raman Sampling Block
13. NeSSI Microreactor Delivery/Calibration System
14. Parker Intraflow System
15. IMM Microreactors and MicroMixers
16. Fuel Cell Research Goal: to study the water uptake properties of Nafion 112 by varying the relative humidity of the input gas streams to better understand membrane hydration and its effects on fuel cell performance.
NeSSI System for gas flow and humidity sensing
17. Where Are We Now? Development continues on control system
Data I/O, comm., and control hardware
Software for DAQ, automation and control
NeSSI microreactor system becoming reality
Parker Intraflow fluidic system designed and being built
IMM, Microglass, CPC mixers and reactor components here or coming soon
LC, Raman, dielectric, RI detection demonstrated or close to
Headspace and media sampling systems
RGA analyzer, Thermo MS systems running
Filter system from CIRCOR functionally tested
Vapochromatic sensor test and development platform operational and providing good results
Large improvement over traditional lab gas handling systems
NeSSI flexibility allows for evolutionary improvements
18. Whats Ahead Continue gas sensing work with focus on application development
Vapochromatic BTEX sensor (array)
Vapochromatic humidity sensor for fuel cells
Fermentation headspace/off-gas monitoring
Continue development of control and acquisition software
Begin characterizing flows and dispersion in the NeSSI systems
Important for analytical and mixing applications
Continue developing analytical interfaces to bring more instrumentation to NeSSI
Working with Vendors of new technology
In-house fiber optic flow cell for NeSSI
19. Acknowledgements Swagelok, CIRCOR, and Parker (NeSSI systems and components)
Brooks Instruments and Flowmatrix (MFCs)
Thermo and Merk/Horiba (Mass Spec.)
Agilent (Dielectric)
IMM, Microglass, and CPC (microreactors)
UOP (server for NeSSI web sites)
ExxonMobil, Kraft, others (applications)
NeSSI Steering Team
CPAC