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Basal gAd(0.25 ug/mL) gAd(1.0 ug/mL) gAd(3.0 ug/mL)

SFig 1A. SFig 1B. ***. ***. *. **. *. *. Basal 0.25 1.0 3.0 0.25 1.0 3.0. Basal 0.25 1.0 3.0 0.25 1.0 3.0. gAd (ug/mL). fAd (ug/mL). gAd (ug/mL). fAd (ug/mL). SFig 1C.

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Basal gAd(0.25 ug/mL) gAd(1.0 ug/mL) gAd(3.0 ug/mL)

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  1. SFig 1A. SFig 1B. *** *** * ** * * Basal 0.25 1.0 3.0 0.25 1.0 3.0 Basal 0.25 1.0 3.0 0.25 1.0 3.0 gAd (ug/mL) fAd (ug/mL) gAd (ug/mL) fAd (ug/mL) SFig 1C. Basal gAd(0.25 ug/mL) gAd(1.0 ug/mL) gAd(3.0 ug/mL) *** ** fAd(0.25ug/mL) fAd(1.0ug/mL) fAd(3.0ug/mL) * Basal 0.25 1.0 3.0 0.25 1.0 3.0 gAd (ug/mL) fAd (ug/mL)

  2. SFig 2A. SFig 2B. pro-MMP-2 (pg)/well pro-MMP-9 (pg)/well 8 16 32 64 128 256 512 125 250 500 1000 2000 4000 8000 Pro-MMP-9 (pg) Pro-MMP-2 (pg) SFig 2C. MMP9 88 kDa MMP2 62 kDa Basal gAd fAd AdR1 AdR2 AdR1 AdR2 VEGF gAd fAd

  3. SFig 3B. SFig 3A. NS *** NS *** % migration (relative to Basal) % proliferation (relative to Basal) Basal CRP CRP+TLR-4 Ab Basal CRP CRP+TLR-4 Ab SFig 3C. *** NS Tube length (% difference) Basal CRP CRP+TLR-4 Ab

  4. SFig 4A. SFig 4B. *** *** NS # Phos/Total AMPK (fold increase over basal) NF-κB activity (RLU) (fold increase over basal) # # Basal gAd 0.01 1.0 10 Basal LPS (100ng/mL) LPS+ mAb HTA-125 (20µg/mL) AdipoR1(μg/mL) +gAd (3μg/mL)

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