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Neurofibromatosis 1 Design Project

Neurofibromatosis 1 Design Project. Varahi Trivedi. Background Info of the Disease. Genetic disorder of the nervous system Results in tumor growth Three types (NF1, NF2,, and Schwannomatosis ). Existing Treatment and Research. No existing treatment to physically stop it

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Neurofibromatosis 1 Design Project

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  1. Neurofibromatosis 1 Design Project • Varahi Trivedi

  2. Background Info of the Disease Genetic disorder of the nervous system Results in tumor growth Three types (NF1, NF2,, and Schwannomatosis)

  3. Existing Treatment and Research No existing treatment to physically stop it Prenatal testing and tumor removal Research done by Children’s Tumor Foundation

  4. Genetic Origin of Disease Located on NF 1 gene of Chromosome 17 Mutations are common on this gene Two major proteins: Neurofibromin and Ras Mutation leads to uncontrolled cell division

  5. How A Mutated Cell Functions Shape of Neurofibromin will become altered Unable to bind with Ras Cell division unregulated and uncontrolled Tumor growth

  6. Proposed Design Step by Step: 1.) Injection of bacteria containing mitochondria into bloodstream and travel to NF1 gene 2.) Bacteria will bind to NF protein and combine the mitochondria with the protein 3.) Bacteria will alter protein shape and mitochondria will retain shape

  7. Expected Results NF protein is vulnerable due to location Mutation’s intentions would become useless because NF protein shape would be restored Inhibit tumor growth

  8. Comparison to Other Treatments Prenatal testing is unreliable in spotting mutations Tumor removal is ineffective because tumors can grow back **Bacteria insertion is promising because it solves the problem at the root**

  9. References/Sources Sources;__http://wsnfsupport.org/about-neurofibromatosis-2/facts-statistics/____http://learn.genetics.utah.edu/content/disorders/whataregd/nf1/__http://learn.genetics.utah.edu/content/begin/dna/neurofibromin/__http://emedicine.medscape.com/article/1177266-treatment____http://www.jneurosci.org/content/23/26/8949.full.pdf____http://www.ctf.org/category/r4r-blog.html____http://ghr.nlm.nih.gov/gene/NF1____http://emedicine.medscape.com/article/950151-overview____http://www.ncbi.nlm.nih.gov/pubmed/14999847____http://www.sciencedirect.com/science/article/pii/S009030199700356X____http://www.millipore.com/references/tech1/7yv3f6____http://learn.genetics.utah.edu/content/disorders/whataregd/nf1/__

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