Optimized Perfusion

1. Optimized Perfusion from Leading today… Leading the way

2. Optimized Perfusion • How do you achieve the lowest prime circuit that safety will allow? • Does your choice of equipment really impact your ability to reduce hemodilution during cardiopulmonary bypass?

3. Optimized Perfusion • The experts at Sorin Group can help you realize your vision of better bypass. • Our products and services have been designed to: • Optimize the effectiveness of your perfusion practice • Help you deliver improved patient outcomes • Reduce the need for blood bank products

4. Optimized Perfusion • An optimally designed cardiopulmonary bypass system can help avoid the administration of transfused blood, which reduces the risk of: • Morbidity and mortality1,2 • Mis-transfusion3 • Acute lung injury3 • Costs3 • Decreased post-op quality of life4 References: 1. Koch CG, et al, Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting. Crit Care Med. 2006 Jun; 34(6):1823-4. 2. Rogers MA, et al, Allogeneic blood transfusions explain increased mortality in women after coronary artery bypass graft surgery. Am Heart J. 2006 Dec; 152(6):1028-34. 3. Thurer RL. Blood transfusion in cardiac surgery. Can J Anaesth. 2001 Apr;48(4 Suppl):S6-12. 4. Koch CG, et al, Persistent effect of red cell transfusion on health-related quality of life after cardiac surgery. Ann Thorac Surg. 2006 Jul;82(1): 13-20.

5. Optimized Perfusion • Additionally, an optimized system can: • Reduce prime volume and hemodilution • Maintain higher hematocrit levels during and after bypass surgery • And, ultimately, help you achieve better patient outcomes • But how do you achieve this while still delivering the best system in terms of clinical viability and patient safety?

6. Optimized Perfusion • What’s needed for an Optimized Perfusion System? • Low Prime Circuit • Biocompatible Technology • Optimized Heart Lung Equipment • Collecting and Returning Shed Blood • Minimally Invasive Vessel Harvesting

7. Components of Optimized Perfusion • Low Prime Circuit • Sorin Group offers several low prime volume devices to help you achieve your optimum configuration. • Examples include: • Apex HP and PrimO2x oxygenators with 250ml priming volume • Sorin arterial filters with 92ml priming volume • CSC 14 cardioplegia device with 28ml priming volume • Plus, our experts can help you optimize line lengths and reduce prime volume while maintaining exceptional hematocrit levels.

8. Components of Optimized Perfusion Biocompatible Technology Sorin Group has developed two stable, non-heparin based surface coatings for bypass circuits. SMARXT and PC biocompatible coatings improve platelet preservation and reduce platelet adhesion to foreign surfaces.1 References: 1. DeSomer, et al. Phosphorylcholine coating of extracorporeal circuits provides natural protection against blood activation by the material surface. European Journal of Cardiothoracic Surgery 18 (2000) 602-606

9. Components of Optimized Perfusion Optimized Heart Lung Equipment The world-leading S5 and C5 heart lung machines from Sorin offer an unparalleled list of safetyfeatures including: Data Management System, providing fully integrated data management including valuable information for implementing a quality improvement program Analysis of data management quality indicators can assist in the most efficient use of an optimized circuit

10. Components of Optimized Perfusion • Optimized Heart Lung Equipment • The unique S5 and C5 Mast Mounted Pumps allow you to reduce both the arterial and venous line lengths to further reduce hemodilution. • In addition, Sorin Group has the Electrical Remote-Controlled (ERC) tubing clamp—an unprecedented safety feature that immediately occludes the arterial line when certain conditions are detected (low level, bubble or retrograde flow).

11. Components of Optimized Perfusion Performance & Safety-enhancing Accessories Our Electrical Venous Occluder (EVO) is a next-generation safety device that helps you achieve controlled and ultra-precise regulation of the venous return flow. Our Electronic Gas Blender enables the operator to deliver precise and accurate gas flow to the patient at all times during a bypass procedure. B-Care5 is the first fully integrated, in-line monitoring system for the vital parameters of venous saturation, hematocrit and venous temperature.

12. Components of Optimized Perfusion Collecting and Returning Shed Blood Creating a successful blood sequestration program within your hospital reduces the cost of and need for allogeneic blood. The patient’s own blood is salvaged using a blood recovery system like the BRAT 2 or Electa from Sorin Group.

13. Components of Optimized Perfusion Minimally Invasive Vessel Harvesting Sorin EVH systems give you the freedom to perform minimally invasive harvesting to suit varying patient anatomies, user techniques and capital equipment.  Patents benefit from a shorter hospital length of stay, less pain, reduced wound complications and improved cosmesis resulting from smaller incisions. Our EVH solutions are open CO2 systems, which carry little to no risk of CO2 embolism. In addition, our systems operate at a lower temperature to reduce the risk of intimal hyperplasia.

14. For More Information… • When you collaborate with the professionals at Sorin Group, the result is a custom-designed cardiopulmonary bypass circuit that achieves a high degree of patient safety. • Sorin Group’s unique Prime Volume Calculator lets you test a wide assortment of scenarios—before making any changes to your circuit! • If you have questions regarding better bypass, call Sorin at 1-800-221-7943.