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Background. PD treatment: Pharmacological therapy SurgeryHowever, disease continues to progress, and increased disabilityPD impacts on patients mobility: Gait impairments Episodes of freezing Increased risk of fallsPhysiotherapy interventions used to: Maximise functional ability M
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1. RCTs of Physiotherapy Interventions in Parkinsons Disease- A Systematic Review
Ms Natalie Ives
8th June 2010
2. Background PD treatment:
Pharmacological therapy
Surgery
However, disease continues to progress, and increased disability
PD impacts on patients mobility:
Gait impairments
Episodes of freezing
Increased risk of falls
Physiotherapy interventions used to:
Maximise functional ability
Minimise secondary complications
Through movement rehabilitation within the context of education and support for whole person
Physiotherapy covers a number of different treatment techniques centred on active exercises and re-education of
mobility
3. Background
In 2001, a Cochrane systematic review was published comparing physiotherapy against a placebo or no intervention for PD (Deane et al, 2001)
Eleven randomised controlled trials (RCTs) were identified with 280 participants
Ten trials noted a positive effect from physiotherapy, but few outcome measures were statistically significant and methodological flaws were noted
Review concluded that there was insufficient evidence to support or refute the effectiveness of physiotherapy for PD
Since then a number of RCTs have been published and so the review requires updating
4. Methods - Trial Identification
Literature search up to end of 2009
Systematic search for RCTs of physiotherapy versus no physiotherapy in patients with PD, sources searched:
Electronic databases
Trials Registers
Conference proceedings
Reference lists
5. Methods - Statistics Continuous data, so extracted means and standard deviations
Data abstracted independently by three authors, with any discrepancies resolved by discussion
Standard meta-analysis methods
Weighted mean difference
Forest plots of change from baseline to end of the treatment period
Investigate overall treatment effect
physio treated patients compared to non-physio treated patients
6. Methods - Statistics
Wide range of approaches employed:
E.g. Standard Physio, Alexander Technique, Treadmill Training, Aerobic Exercise, Tai Chi, Waltz
Trials classified depending on type of physio:
Physiotherapy vs. control
Exercise vs. control
Treadmill vs. control
Cueing vs. control
MDT Rehab vs. control
Dance vs. control
Martial Arts vs. control
compared using tests of heterogeneity, both over trials & subgroups of trials
7. Outcome Measures
8. Results - Trials
9. Trial Classification
10. Results Walking Outcomes
11. Results Velocity (m/s)
12. Results Other Physio Outcomes
13. Results Timed Up and Go (s)
14. Results Functional Reach (cm)
15. Results Berg Balance Scale
16. Results PD Outcomes
17. Results UPDRS ADL
18. Results UPDRS Motor
19. Summary Velocity, TUG & functional reach significantly improved in physio groups
Suggests improvement in functional mobility
Berg balance significantly favoured intervention
Positive effect on falls
Falls data limited for meta-analysis
UPDRS significantly favoured intervention
Particularly motor symptoms
Suggests improvement in PD symptoms
20. Conclusion Updated review provides some clearer evidence on the possible benefit of physiotherapy in the treatment of PD
However, most of the observed differences between treatments were small
Studies included in this review are relatively small, so larger placebo controlled RCTs needed
PD Rehab (n=750)
21. Acknowledgements Claire Smith
Smitaa Patel
Rebecca Stowe
Charmaine Meek
Carl Clarke
Cath Sackley
Parkinsons UK
24. Results PD Outcomes
25. Results UPDRS Total
26. Results UPDRS Total
27. Results UPDRS ADL
28. Results UPDRS Motor
29. Results PDQ-39 Summary Index
30. Results Multiple Arm Trials
31. Conclusion Many different types of intervention, some have greater effect than others
Physio vs. Physio review in progress
Physio intervention improves functional mobility, balance, PD symptoms and QoL
Evidence available supports use of physio interventions in PD
Studies included in MA are relatively small, large placebo controlled RCTs needed
PD Rehab