Frontiers in Bioscience Research Institute: Fighting Cancer and Aging

1. Your gift or donation is tax deductible About Frontiers in Bioscience Research Institute Frontiers in Bioscience research institute in aging and cancer was launched in 2011. The mission of the institute is to find cure for cancer, identify pathways for reversal of aging and to provide a forum for public education and fund raising. Scientists at the institute will examine innovative non-radiotherapeutic and non-chemotherapeutic approaches for treatment of all solid cancers. New ideas that can reverse the age induced damage to DNA and cell organelles will also be pursued. The institute will also launch a rejuvenation clinic for slowing down the speed of aging. Interested individuals can contact the institute for further information. The institute will be funded through tax deductible donations, fund raising events, and educational programs. Various galleries participate in fund raising through providing artworks that are gifted to philanthropic donors. Support us Frontiers in Bioscience Research Institute 16471 Scientific Way Irvine, CA 92618 www.bioscience.org/ri.htm fbs@bioscience.org

2. Help us to Help you If you have a philanthropic nature, you will enjoy your partnership with us Support us Siamak Tabibzadeh obtained his MD degree in 1977, was board certified in Pathology in 1982 and became assistant professor in Pathology in 1983. He was promoted to the rank of associate professor and then to the position of full professor at University of South Florida in early 1990s and obtained full professor position at Stony Brook University in 2000 and at UCI in 2011. Dr Tabibzadeh has authored over 100 publications, has six patents and cloned one of the human genes (EBAF/LEFTY) in 1997. Dr Tabibzadeh established Frontiers in Bioscience journal in 1996 which is now recognized as one of the top 50 biology journals in the world. Dr Tabibzadeh founded the Frontiers in Bioscience Research Institute in Aging and Cancer in 2011 in pursuit of finding a cancer cure and pathway(s) to the reversal of aging. Dr Tabibzadeh is committed to making the research institute to be one of the pre-eminent research centers for excellence in science. Selected Publications Satyawaroop PG, Tabibzadeh S Extracellular matrix and the patterns of differentiation of humanendometrial carcinomas In vitro and In vivo. Cancer Res 51:5661- 5666, 1991 Siamak Tabibzadeh, MD President, Full professor Frontiers in Bioscience Research Institute in Aging and Cancer tabibzadeh@bioscience.org

3. Help us to Help you Support us JM Mason, Hao-Peng Xu, Srinivasa. K. Rao, Andrew Leask, M Barcia, Jidong Shan, Robert Stephenson, S Tabibzadeh Lefty contributes to the remodeling of extracellular matrix by inhibition of CTGF and collagen mRNA expression and increased proteolytic activity in a fibrosarcoma model. J Biol Chem 4, 407-415, 2002 http://www.jbc.org/cgi/reprint/277/1/407.pdf Tabibzadeh S Homeostasis of Extracellular Matrix By TGF-BETA and LEFTY Front Biosci 7, d1231-1246, 2002 Li J, Kokkola R, Tabibzadeh S, Yang R, Ochani M, Qiang X, Harris HE, Czura CJ, Wang H, Ulloa L, Wang H, Warren HS, Moldawer LL, Fink MP, Andersson U, Tracey KJ, Yang H. Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med. Jan-Feb;9(1-2):37-45. 2003 Tabibzadeh S, Hemmati-Brivanlou A LEFTY at the crossroad of 'stemness' and differentiative events. Stem Cells. 24, 1998-2006, 2006 doi:10.1634/stemcells.2006-0075 PMid:16728558 R Kothapalli, I Buyuksal, S-Q Wu, N Chegini, S Tabibzadeh Detection of EBAF, a novel human gene of the TGF-beta superfamily; association of gene expression with endometrial bleeding. J Clin Invest 99, 2342-2350, 1997 http://www.jci.org/cgi/reprint/99/10/2342.pdf PubMed No 9153275 Tabibzadeh S, Mason J, Cai Y, Wendy S, Murray MJ, Lessey B Dysregulated expression of EBAF, an occult and novel molecular defect in the endometria of patients with infertility. J Clin Endocrinol Metab 85, 2526-2536, 2000 http://jcem.endojournals.org/cgi/reprint/85/7/2526.pdf doi:10.1210/jc.85.7.2526 Ulloa L, Creemers JW, Roy S, Liu S, Mason J, Tabibzadeh S. Lefty proteins exhibit unique processing, and activate the MAP kinase pathway. J Biol Chem 276, 21387-21396 (2001) http://www.jbc.org/cgi/reprint/M006933200v1.pdf doi:10.1074/jbc.M006933200 PMid:11278322 Ulloa L, Tabibzadeh S Lefty inhibits R-Smad phosphorylation induced by activated TGF-beta receptor J Biol Chem 276, 21397-21404 (2001) http://www.jbc.org/cgi/reprint/M010783200v1.pdf doi:10.1074/jbc.M010783200 PMid:11278746

4. Help us to Help you Support us Gaetan Mayer, Josee Hamelin, Marie-Claude Asselin, Antonella Pasquato, Edwidge Marcinkiewicz, Meiyi Tang, Siamak Tabibzadeh, and Nabil G. Seidah The regulated cell-surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates. J Biol Chem 283(4), 2373-2384. 2008 doi:10.1074/jbc.M708763200 PMid:18039650 Devendra G Naidu, Meiyi Tang, Siamak Tabibzadeh Lefty peptides, derived by MMP2 cleavage, act as a new class of gelatinase A inhibitor. Front Biosci 13, 7193-7201, 2008 Meiyi Tang, Devendra Naidu, Patrick Hearing, Stuart Handwerger, and Siamak Tabibzadeh LEFTY, a member of the TGF-beta superfamily, inhibits uterine stromal cell differentiation. A novel autocrine role. Endocrinology. 151, 1320-1330, 2010

5. Help us to Help you If you have a philanthropic nature, you will enjoy your partnership with us Support us Daniel Tabibzadeh, a graduate of Stony Brook University, obtained his bachelor’s degree in the biological sciences in May of 2011. As an avid follower of technology, Daniel believes that the future of biology will eventually become intertwined with computer technology, in that “biotechnology” will heavily associate with computers and ultimately artificial intelligence. As such, Daniel has begun a new undertaking; to elevate the Frontiers in Bioscience journal to new heights and also facilitate the “back-end” automation of various programming-related methodologies of manuscripts. Daniel acts as a “consultant” for core decisions such as Website re-design and other major accords. Daniel will also participate in the funding decisions of FBS and ongoing activities at the research institute and will be responsible for all budgetary matters. Daniel Tabibzadeh Development Manager Frontiers in Bioscience Research Institute in Aging and Cancer dan@bioscience.org

6. Your gift or donation is tax deductible Become part of Frontiers in Bioscience Research Institute We invite you to participate in FBS research, fund raising and educational programs and become a member of Frontiers in Bioscience Research Institute. As a member, you will be qualified to be on our lifetime roster of participants in our educational programs, receive beautiful artwork for your contribution, and add the name of your family or institution in the FBS Auditorium. The Auditorium is central to the activity of the Institute. The FBS Auditorium serves as a valuable meeting place for the Institute faculty, staff and guests. The Auditorium will also host members who will participate in our educational programs and become aware of science in the institute and witness the growth of scientists who are funded by their generous contributions. Each of the 120 seats in the Auditorium is available for sponsorship. Sponsors may chose any available seat with a gift of $1,000-50,000 that designates their permanent seat at the institute. An engraved nameplate will be prominently affixed to a seat in this unique venue in our beautiful newly designed building. These are our ways of saying thank you to your generous support to one of the nation’s first independent research institute. We are dedicated and committed to understanding the means for aging reversal and new non-toxic approaches for the treatment of cancer and need your support to help you and humanity. Support us Frontiers in Bioscience Research Institute 16471 Scientific Way Irvine, CA 92618 www.bioscience.org/ri.htm fbs@bioscience.org

7. Help us to Help you and your loved ones Become part of Frontiers in Bioscience Research Institute Using the most modern research advances, FBS Research Institute will focus on reversal of the aging process and in treating cancer by non-radiotherapeutic or chemotherapy approaches. Over the past several decades, competing national priorities have restricted the National Institutes of Health (NIH), the primary federal agency that funds biomedical research to support diverse research initiatives of scientists across the US. For this reason, private support for basic research is now more important than ever particularly when there is no technical block in the progress of science. Philanthropic gifts to the Frontiers in Bioscience Research Institute will lead to real change in biomedical research aimed at extending the healthy years of our lives and in cancer treatment. Gifts and private funds from individuals, families, foundations and corporations can place Frontiers in Bioscience Research Institute on an accelerated pace of discovery. Scientists at the institute have the flexibility to follow promising leads and identify new approaches before they become eligible for NIH grant support. These fundings will also support the institute to recruit the most talented scientists who are committed to make Landmark discoveries. Please consider to support us in our mission to helping humanity. Funding Resarch at FBS RI Become Part of the FBS Institute Contact Frontiers in Bioscience Research Institute Development fbs@bioscience.org 16471 Scientific Way, Irvine CA 92618

8. Support us Our Funding Priorities Support New Reversal of Aging Research Building We plan to develop a clinic for aging reversal for the public. Our target date for the construction of this facility is Jan 1, 2015. This is a clinic for implementation of procedures that insure reversal of aging of the participants. Interested individuals can send their letter of interest to us for participation in our endeavors and for reversal of aging of their loved ones. Support Foundation Grants Research grants from foundations do not provide funding for indirect administrative cost. Your support will supplement such funds that are generally not paid by Research grant foundations. Support Recruitment of New Scientific Faculty During the past several decades, there has been a sharp decrease in the amount of funds that support research in the US through National Institutes of Health (NIH). Particularly, this has impacted young scientists who have the hope to helping humanity but fail to secure funds for their research on aging and cancer. The average age of funding has risen to 41 and the funding rate stands at a dismal rate (5-7%) in various study sections of NIH. Great advancement in techniques in medicine, has made it feasible to pursue and find breakthroughs that will change medicine in this decade. We anticipate that by the year 2020-2030, many of human diseases including cancer and aging, will be curable. However, finding such treatments require funding that currently is not available through NIH or other funding agencies. Your contribution will make this feasible. The Institute seeks to add 10 new Faculty positions by 2015 and will need to spend $2 - $3 million to recruit, equip, and provide the initial support for each of the new scientist. Similar funds not available from granting agencies and private funds are required to start new scientists on their road of discovery. A gift of $2.5 million entitles the donor to name the position in perpetuity (“Endowed Professorship”). Support of New “High-Risk, High-Payoff” Research Initiatives Federal granting agencies, by nature, only fund research proposals that are low risk but these research endeavors add only marginally to science when executed to their completion. Most advances in medicine, however, have occurred through private contributions that support “high risk” but “high pay-off” research. The Institute actively seeks contributions for support of these “high-risk” approaches that are likely to bring sweeping changes in medicine. Among them are approaches for non-radiotherapeutic and non-chemotherapy approaches for treatment of cancer and aging reversal that are not currently funded by NIH or other Federal agencies due to their high risk nature. Support of Student Science Education The Institute actively seeks gifts, and other forms of contributions and corporate sponsorships to educate talented students who consider science research as a possible career goal. Your contribution will support such gifted individuals to find their way in research and allow us to train them to be future scientists. Support of Community Education in Aging and Cancer The Institute hosts highly popular and thought provoking Seminars in a wide array of subjects but particularly those that address treatment of cancer or reversal of aging. Institute scientists and highly recognized external scientists will deliver their work on cutting edge technology, and breakthroughs in medicine and research on aging and cancer in our quarterly lectures in the FBS Auditorium. The Institute seeks gifts and corporate sponsorships in support of these Lecture series and highly exceptional educational programs. Support for Purchase of scientific equipments Your gift goes a long way to allow us to continue to purchase expensive research equipments that are difficult to purchase with Federal grants. Such equipments are required for our research that uses such equipment for data generation or for data mining and analysis Mission Statement Editorial Profile FBS Delivers Support us Frontiers in Bioscience Research Institute 16471 Scientific Way Irvine, CA 92618 fbs@bioscience.org

9. Accelerate science by your donation How to donate to Frontiers in Bioscience Research Institute • Support Research on Aging and Cancer. Make a Gift Today. • The Frontiers in Bioscience Research Institute is one of the nation's only independent research facility focused on aging reversal and non-radiotherapeutic and non-chemotherapeutic treatment of cancer. We need your support for basic science research, expansion of the facility and its staff and opening a clinical center for aging reversal. • Accelerate Science by your tax deductible contribution • Here are ways that you can contribute funds in support of research and education at the research institute. • Purpose of donation • Your donation can be in response to one of our request for fund • New Reversal of Aging Research Building • Foundation Grants • Recruitment of New Scientific Faculty • New “High-Risk, High-Payoff” Research Initiatives • Student Science Education • Community Education in Aging and Cancer • Purchase of scientific equipments • Forms of donation • Bequests (form available upon request) • Wills (form available upon request) • A Tribute to honor friends and family • Contribute funds as a memorial gifts to the legacy of your loved ones • Donate in honor of your friends and relatives for their birthday, wedding • Make a gift for special kindness or generosity that anyone has extended towards you and your family • Frequency of donation • One time donation • Recurring donations • Donation Level • $50 • $100 • $1000 • $5000 • $20000 • Other $ • Dedication • on behalf of • in memory of • Privacy Preference • Provide my full contact information • Provide my contact name and email address only • Provide none of my personal information (anonymous) • Contact Information • First Name • Last Name • E-mail • Phone • Billing Information • Address • Giving Options • Check • Security (form available upon request) • Money order • Other • Credit card • Credit card type (Please mark one) 0 Visa 0 American Express 0 Master Card 0 Discover • Name as it appears on the card • First Name • Last Name • Card Number • Expiration date • Card Address (address to which credit card statement is sent) • Institution (skip if not an institutional card) • Address • Tel • Fax • E-mail

10. Accelerate science by your donation How to donate to Frontiers in Bioscience Research Institute Donate by mail You can send us check, or any form of payment (credit card, money order, security such as stock, bond, mutual fund or other equities, land, or any form of transferrable asset). Please send us your contribution with a letter describing your specific interest in donating to special fund raising requests of FBS (Aging research, Cancer Research, Educational program or becoming a member). Please also provide us with your full name, address and contact information including your phone number and Email. You will be contacted upon receipt of the fund and we will invite you to join us for a tour of the Research Institute. During this tour, you can choose from arts at the institute or you can go online to the gallery WebSite, choose the art that is consistent with the level of your donation and the art will be sent to the address you specify in your letter. If you are not interested in the art work displayed at the institute or online, we offer you other gifts including travel expenses or you can choose from an inventory of gifts that are available to our donors. If you prefer contact us by Email first so that we can contact you to help you towards your donation process. Contact us Please mail your donation and letter of interest to Frontiers in Bioscience Research Institute in Aging and Cancer 16471 Scientific Way Irvine CA 92618 Write to us at fbs@bioscience.org Or contact our representative Contact Frontiers in Bioscience Research Institute Development fbs@bioscience.org 16471 Scientific Way, Irvine CA 92618

11. Accelerate science by volunteering Become a Volunteer at the institute Volunteering is integral to the success of our mission to reverse aging and provide treatment for all human solid cancers. The Institute greatly values and will be indebted for contribution of all those who wish to provide us with their time, support, and expertise. The institute offers a diverse array of volunteering opportunities. You can help us in direct research, or provide us with administrative assistance or extend your help in any other form such as fund raising, educational programs that you find suitable. Most people are able to provide support at many different levels. Please contact us if you like to participate in our mission and endeavors. We would be happy to discuss with you the type of help that you wish to extend to this institution. Current Opportunities: Receptionist assistance Technology or research assistance Administrative assistance Fund raising assistance Educational program assistance Contact us For more information about current opportunities or to learn more about our volunteering program, please contact: fbs@bioscience.org

12. Help us to Help You and Your Loved ones Enrich your life with beautiful art Your tax deductible contribution will support research in aging and cancer. All of us age and most of us have a family member who has cancer or develops cancer as they age. Your contributions will fuel research at Frontiers in Bioscience Research Institute and you are invited to visit our laboratories to see the progress that we are making towards the treatment of cancer, and slowing or reversing aging. You will receive an artwork made by well known artists that can be viewed within the institute or at the Gallery WebSites. The artwork is our way of thanking you for your generosity in supporting our mission and initiatives. All arts at the institute carry special colored tags identifying the artwork that is received for each contribution. Donate and receive an artwork to be cherished for a lifetime

13. Help us Help you Support us Mandarin Fine Art Gallery Mandarin Fine Art Gallery features an eclectic selection of Chinese Contemporary Art. All of the artists represented are world-class emerging and mid-career artists currently living in China and Tibet. The styles range from realism to expressionism, and from surrealism to abstract. With tremendous talent and deep intriguing conceptual framework, these artists create magnificent arts pertinent to the modern day China and China's relation to the world. The subject matter varies from Chinese urban scenes to the most remote and isolated places such as Tibet and Liangshan. With artwork that is refreshingly thought-provoking, aesthetically appealing, and culturally relevant, Mandarin Fine Art Gallery is committed to bringing the finest Chinese Contemporary Art to America and the Western World. Mandarin Fine Art Gallery www.mandarinfineart.comjohn@mandarinfineart.com 949-376-9608 If you love art, you love arts from Mandrin Fine Art Gallery Receive a beautiful piece of art as a gift today.

14. Help us Help you Support us Kamran Khavarani Art, Abstract Romanticism Early life Born into an artistic family, Khavarani started painting at a very young age. When he was twelve years old, he began to study classical painting with the well-known artist, Reza Samimi. Khavarani completed his education in 1966 from Tehran University with a Master’s degree in Architecture and a Ph.D. in Urban Design. His graduate work was done under the guidance of his mentor Master, Hooshang Seyhoun, the internationally renowned Iranian authority in art and architecture Influences Khavarani’s earlier paintings were influenced by his classical and formal training in arts and architecture. Since his recent encounters with the philosophy of Rumi and other great teachers, both the artist and his art have been transformed and his current paintings carry subtle mystical messages. Kamran Khavarani’s paintings represent a rare fusion of the philosophical and metaphysical with the aesthetic, and they draw viewers into the inner world. Professor Boime wrote about Khavarani in his last book; If you love art, you love arts from Kamran Khavarani Art Gallery Receive a piece of art as a gift today.

15. Help us to Help you Support us “The Birth of Abstract Romanticism: Art for a New Humanity, Rumi and the Paintings of Kamran Khavarani’: “Exalted by the love poems of the Persian poet Jalaluddin Rumi (1207-73), Khavarani seeks to translate his ecstatic feelings into visual harmonies that celebrate the idea of Presence, the loving, creative side of existence potentially in everything and everyone.” In The Birth of Abstract Romanticism, Professor Boime explored the details and effects of the artist’s style: “… Khavarani visually expresses his inner response to Rumi, evoking the oceanic and cosmic metaphors of the Persian mystic…Assigning to each of the four elements (earth, air, fire and water) its own unique color register, he gives his primordial visions - most evident in his glowing 'Creation' (2003) - a riveting presence. His skies and seas are saturated in unprecedented, emotional blue-greens, purples and oranges, and his mountain forms are often surrounded by a web of shadowy halos that convey a misty sensory impression of a world still in formation.” If you love art, you love arts from Kamran Khavarani Art Gallery Receive a piece of art as a gift today.

16. Help us Help you Support us In an open letter on July 28, 2008, Professor Boime wrote: “…Khavarani resurrects the romantic possibility that art can change the world by reaching out unstintingly to the heart and imagination of the individual spectator.” As Professor Boime wrote in the conclusion of The Birth of Abstract Romanticism, “It remains to be seen how the fallout from Khavarani’s painting will influence the history of art. Certainly his work goes against the grain of most international contemporary art and in fact purports to offer an alternative to it…‘Beauty’ is certainly the key word in Khavarani’s lexicon, as it represents the quality he has made it his life’s ambition to express—a harmonizing force to offset the ‘ugliness’ of so much bacchanalian and barbaric display that presently passes for art.” If you love art, you love arts from Kamran Khavarani Art Gallery Receive a piece of art as a gift today.

17. Help us Help you Support us Technique Khavarani paints with his hands encased in plastic gloves and by working flatly in oil on paper. He uses his whole hand, in almost dancing motion, and one barely detects the tracks of his labor. As Professor Boime wrote in his book, Khavarani “… has perfected this unique method that produces remarkable results, even at the micro level.” Awards Khavarani has won numerous architectural awards such as ‘California Building Official’s highest award of excellence’ for a single family residence, and the design award for the city of Beverly Hills in a commercial category. His “art-scaping” design has been recognized and published in Japan’s most prestigious landscaping magazine for three consecutive years. Kamran Khavarani Art Gallery www.khavarani.com 310-650-7726 Cell kamran@khavarani.com If you love art, you love arts from Kamran Khavarani Art Gallery Receive a piece of art as a gift today.

18. Donate to Frontiers in Bioscience Research Institute Frontiers in Bioscience Research Institute 16471 Scientific Way Irvine CA 92618 Contact us fbs@bioscience.org