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Lecture 21

Lecture 21. QUESTIONS? Text 37607 Msg : 118916 Question. QUESTIONS? Goto http://pollev.com/ucibio Enter question. Energy matters…. Each cycle generates:. Acetyl CoA  TCA. FADH 2. NADH. -ATP? +ATP?. Energy. Hormonal regulation. The TCA. The brain problem….

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Lecture 21

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  1. Lecture 21 QUESTIONS? Text 37607 Msg: 118916 Question QUESTIONS? Gotohttp://pollev.com/ucibio Enter question

  2. Energy matters… Each cycle generates: Acetyl CoA  TCA FADH2 NADH -ATP? +ATP?

  3. Energy

  4. Hormonal regulation

  5. The TCA

  6. The brain problem… Most energy stored as fatty acids Brain only uses Glc Fatty acids  Glc? How does brain function during starvation?

  7. Production of ketone bodies Starvation  Glycogen = 1 day Amino acids  Glc. BUT… Muscles can use fatty acids ( need for Glc) Gluconeogenesis OAA, so TCA Without TCA, liver makes “Ketone bodies” from fats

  8. Ketone bodies

  9. Diabetes & ketone bodies Starvation  KB  Used by brain Extreme starvation  Muscle breakdown No insulin  Blood sugar, AND FA breakdown Too much Acetyl CoA  Brain has plenty of Glc! ___________ in blood = pH  Death

  10. If only…

  11. Making fatty acids = adding 2 Cs to chain!

  12. AcCoA Malonyl CoA

  13. FAS

  14. ACP in FAS

  15. FAS

  16. Fatty acid synthesis

  17. Substrate shuttling in FAS

  18. Substrate shuttling in FAS

  19. Further steps…

  20. Further steps…

  21. Regulation of FAS & breakdown

  22. Regulation of FAS & breakdown AMP-dep Protein Kinase Ac CoA Glucagon ACC-P ACC Malonyl CoA Citrate Protein phosphatase Palmitoyl CoA Insulin

  23. Allosteric regulation of ACC

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