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Immunotherapy

Immunotherapy. Personal statistics (updated, 2013) John Weisnagel, M.D. Database . Sept 1992-Dec 2012: 31,150 patients Undergoing immunotherapy: 2,533 pts (8%) Perennial Rx (all-year long): 1,490 (58.8%)

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Immunotherapy

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  1. Immunotherapy Personal statistics (updated, 2013) John Weisnagel, M.D.

  2. Database • Sept 1992-Dec 2012: 31,150 patients • Undergoing immunotherapy: 2,533 pts (8%) • Perennial Rx (all-year long): 1,490 (58.8%) • Pre-seasonal Rx (one injection per week (for 4 or 9 weeks depending on type of Rx, 1-2 months preceding the specific pollen season): 1020 (40.2%) • 23 pts having rec’d both types of treatment.

  3. Efficacy of immunotherapy • Of the 2,533 treated since 1992, • 1046 replied to the question of the effect of their treatment (excellent, very good, good, slight or no change) when reminders were sent them about renewals • Treatment was: • Perennial in 596 • Pre-seasonal in 450

  4. Perennial Treatment • 596 patients: • Asthma: 53 (8.8%) • Asthma + pollinosis: 74 (12.4%) • Asthma + rhinitis: 86 (14.4%) • Pollinosis: 155 (26%) • Rhinitis: 225 (37.7%)

  5. Efficacy of Perennial treatment in 596 patients

  6. Pre-seasonal Treatment • 450 patients with pollen allergy, some with associated asthma: Reported effect: Excellent in 82 (18.2%) Very good in 135 (30%) Good in 111 (24.6%) Slight in 48 (10.6%) Ineffective in 24 (5.3%)

  7. Efficacy summary • Perennial treatment averaged : • 18.5% for slight improvement • 28.9% for good “ • 30.3% for very good “ • 10.1% for excellent “ • while ineffective in only 11.8% • Pre-seasonal treatment averaged: • 10.6% for slight improvement • 24.6% for good “ • 30% for very good “ • 18.2% for excellent “ • while ineffective in only 5.3%

  8. Pre-seasonals • Center-Al™ • Suspal™ • Pollinex R™ • Other tyrosine preps.

  9. Perennials • Mixtures: • House dust mite + pollens • House dust mite + molds • House dust mite + pollens + molds

  10. Bottom line • These personal statistics, though anecdotal, reflect the conclusion of the many studies published on the benefit of immunotherapy. • Both forms of therapy, perennial and pre-seasonal have similar benefits. • Immunotherapy is still an effective treatment in respiratory allergy, and should be considered when pharmaceutical therapy is inadequate.

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