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Dejean_FigS1

A. B. *. 10.0. 7.5. *. Relative amount of VEGF mRNA. 5.0. 2.5. 0.0. ALK. n=4. + n=4. - n=4. + n=4. - n=4. tTA. ALK+ no Dox. ALK- With Dox. *. *. tTA. NPM-ALK. TPM3-ALK. C. 40. 30. Amount of secreted VEGF (pg/ml). 20. 10. 0. + n=5. - n=5. + n=5. -

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Dejean_FigS1

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  1. A B * 10.0 7.5 * Relative amount of VEGF mRNA 5.0 2.5 0.0 ALK n=4 + n=4 - n=4 + n=4 - n=4 tTA ALK+ no Dox ALK- With Dox * * tTA NPM-ALK TPM3-ALK C 40 30 Amount of secreted VEGF (pg/ml) 20 10 0 + n=5 - n=5 + n=5 - n=5 ALK n=6 tTA NPM-ALK TPM3-ALK Dejean_FigS1

  2. ALCL-10 ALCL-21 ALCL-22 ALCL-25 ALCL-27 ALCL-29 ALCL-32 ALCL-33 ALCL-35 ALCL-37 ALCL-38 ALCL-39 ALCL-40 ALCL-53 H20 UC MC Methylated DLEU2 (176bp) hsa-miR-16-1 Non-methylated DLEU2 (181 bp) Methylated SMC4 (240 bp) (1) Non-methylated SMC4 (238 bp) (1) hsa-miR-16-2 Methylated SMC4 (169bp) (2) 1000 ** 750 Relative miR-16 expression Non-methylated SMC4 (171 bp) (2) 500 250 0 Sc miR-16 Dejean_FigS2 Dejean_FigS3

  3. ALCL-22 ALCL-27 ALCL-39 ALCL-33 Dejean_FigS4

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