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Key Concept of Immunology

Key Concept of Immunology. Dr Alok Tripathi Department of Biotechnology 09795894495 aquaimmuno@yahoo.co.in. I. EVOLUTION OF THE IMMUNE SYSTEM . Phylogeny of vertebrate and invertebrate immunity (see Fig. JL-1 and Fig. JL-2) Self vs not-self: Graft rejection:

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Key Concept of Immunology

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  1. Key Concept of Immunology Dr Alok Tripathi Department of Biotechnology 09795894495 aquaimmuno@yahoo.co.in

  2. I. EVOLUTION OF THE IMMUNE SYSTEM • Phylogeny of vertebrate and invertebrate immunity • (see Fig. JL-1 and Fig. JL-2) • Self vs not-self: • Graft rejection: • CMI - humoral immunity: • Bi-functional system • Epithelium from gills of fish-Lymphoid Organ

  3. II. HISTORICAL PERSPECTIVES • Exp. I. Vaccine vs fowl cholera • “Serendipity” • Attentuation of virulent cultures • Exp. II. Vaccine vsBacillus anthracis (1881) • Attenuated bacillus cultures • immunized sheep • Exp. III. Immunizing human against rabies • Joseph Meister • Ethics?

  4. Antigen Antibody

  5. Adaptive Heightened response

  6. Secret Ab

  7. TH cells APCs Tc cells (CTLs) - lyse virus infected cells B cells - produce Abs

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