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Outcomes among patients with HIV-associated Tuberculosis in Guangxi, People’s Republic of China

Outcomes among patients with HIV-associated Tuberculosis in Guangxi, People’s Republic of China. Zhang Yao, Yu Lan, Ma Ye, Zhao Yan, Sun Kai and Zhang Fujie Division of Treatment and Care National Center for AIDS/STD Chinese Center of Disease Control and Prevention . Background.

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Outcomes among patients with HIV-associated Tuberculosis in Guangxi, People’s Republic of China

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  1. Outcomes among patients with HIV-associated Tuberculosis in Guangxi, People’s Republic of China Zhang Yao, Yu Lan, Ma Ye, Zhao Yan, Sun Kai and Zhang Fujie Division of Treatment and Care National Center for AIDS/STD Chinese Center of Disease Control and Prevention

  2. Background TB is the most common co-infection in HIV infected population. China is a high TB burden country with a growing HIV epidemic. HIV-associated TB – a particular problem due to its high mortality, diagnostic challenges, and complicated simultaneous treatment of both infections – is therefore a growing concern in China. Yet outcomes among patients with HIV associated TB in China are not well characterized.

  3. Objective • This study seeks to evaluate the magnitude and determinants of survival among HIV infected patients with culture positive tuberculosis seeking care in the public health system in Guangxi province, China.

  4. Design & Patients Retrospective cohort study. Patients were identified from a cross sectional TB screening project during 2006-2008. Adult(>18y) HIV+ patients with a positive TB culture from any body fluid were included and followed until 12 month after TB diagnosis, or death, loss to follow-up, or transfer if earlier.

  5. Study sites Total population: 10 million HIV prevalence: 0.1% TB prevalence in PLWH: 20%

  6. Treatment guidelines • ART starting criteria: changed from CD4<200 to CD4<350 in 2008 • ART regimen: AZT(d4T) + 3TC + EFV(NVP) • Timing of ART initiation in ART-Naïve patients with active TB: CD4<200: 2–8 weeks after TB therapy initiation CD4=200-350: after 8 weeks TB induction period CD4>350: after completion of TB therapy • TB regimen: RHZE x 2months then RH x 4months, adjusted according to drug resistance testing

  7. Measurements Primary outcome of interest: all cause mortality within first 12 months of TB diagnosis. Clinic records were reviewed at 12 month after the TB diagnosis to ascertain vital status, then confirmed with national HIV database. Socio-demographic and clinical information were extracted from patients’ charts. Liquid culture(BacT/Alert) was used for diagnosis and TB drug resistance testing for isoniazid, rifampin, ethambutol, streptomycin.

  8. Statistical analysis The Kaplan–Meier method was used to estimate the probability of death after TB diagnosis. Cox regression was used to determine risk factors associated with mortality. Logistic regression was used to determine factors associated with receipt of TB therapy and ART.

  9. Results-baseline characteristics (n=201)

  10. Sources of culture samples by location, n(%) Sputum 168 (84) Lymph node aspiration 39 (19) Blood 22 (11) Stool 11 (6) Cerebral Spinal Fluid 7 (4) Pleural fluid 7 (4) Note: some patients had positive cultures from more than one sources.

  11. Drug resistance pattern of 156 M.tuberculosis strains

  12. TB and ARV Treatment Coverage (67%)

  13. Results – 1 year clinical outcomes Total=201 Alive: 123 (61%) Dead: 47 (23%) Transferred: 17 (9%) LTFU: 14 (7%) Accumulative Survival =75% (95%CI, 69-81%)

  14. Risk Factors Associated with Death * Adjusted for gender, age, mode of transmission, CD4 at study entry, extrapulmonary TB, TB drug resistance and ART status at study entry

  15. Survival of patients by Treatment status HR=1;ref AHR=6; CI [3-13] AHR=7; CI [3-18] AHR=24; CI [9-62]

  16. Factors associated with death or LTFU * Adjusted for gender, age, mode of transmission, CD4, extrapulmonary TB, TB drug resistance, and ART status on study entry

  17. Factors associated Receiving ARV * Adjusted for gender, age, BMI, mode of transmission, baseline CD4, CXR, and sputum smear

  18. Factors associated with TB Treatment * Adjusted for gender, age, literacy, marital status, mode of transmission, BMI, baseline CD4, EPTB and sputum smear

  19. Conclusions and implications This cohort of HIV+ Chinese adults with culture-positive TB demonstrated high tuberculosis drug resistance rate, high 1 year mortality and lower-than-expected treatment coverage. These findings implicate that strengthening integrated administration of ART and TB therapies are critically important in this setting.

  20. Acknowledgement Sponsors: Clinton Foundation, Global Fund Guangxi Province Health Department: Drs. Liu Wei, Tang Zhirong, Lu Hongyan Liu Zhou CDC: Zheng Yuanjia, MD Naning 4th Hospital: Huang Shaobiao, MD University of California, San Francisco: Elvin Geng, MD University of North Carolina: Zhu Hao, Ph.D National Institute of Health: Ray Y, Chen, MD University of California, Los anginas : Wen Yi, Ph.D World Health Organization: Fabio Scano Washington University: Maurer Kristin

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