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Factors influencing release

Factors influencing release. size of drug particles. Factors influencing release. rate and extent of disintegration choice and conc’n of disintegrant. Factors influencing release. choice and conc’n of lubricant. compression pressure. Processing Problems. capping, lamination, chipping.

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Factors influencing release

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  1. Factors influencing release • size of drug particles

  2. Factors influencing release • rate and extent of disintegration • choice and conc’n of disintegrant

  3. Factors influencing release choice and conc’n of lubricant compression pressure

  4. Processing Problems • capping, lamination, chipping

  5. Processing problems • sticking • mottling • weight and hardness variation

  6. Tablet Evaluation • these tests are mandatory in the US and the procedures are outlined in the USP • dose uniformity • by weight variation • by content • disintegration

  7. Dissolution testing

  8. Unofficial tests mechanical strength • attrition resistance (friability) • fracture resistance • porosity

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