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HIV & Pregnancy

HIV & Pregnancy. Dr. med. Annette E. Haberl Universitätsklinikum Frankfurt am Main Infektionsambulanz. Frankfurt HIV-Cohort Patients May 2000 - May 2001 (n=2465). 1898 (77%). 567 (23%). Frankfurt HIV-Cohort: Increase of Patients. 24%. 22%. 36%. 19%. 19%. 24%.

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HIV & Pregnancy

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  1. HIV & Pregnancy Dr. med. Annette E. Haberl Universitätsklinikum Frankfurt am Main Infektionsambulanz

  2. Frankfurt HIV-CohortPatients May 2000 - May 2001 (n=2465) 1898 (77%) 567 (23%)

  3. Frankfurt HIV-Cohort: Increase of Patients 24% 22% 36% 19% 19% 24%

  4. Frankfurt HIV-Cohort: Pregnancies since January 1999 • all pregnancies: 78 • born children to date: 57 (1999: n=15; 2000: n=27; 2001: n=15) • missed abortions: 4 • interruption (medical reasons): 1 • ongoing pregnancies: 16 1. May 2001

  5. Frankfurt HIV-Cohort: Characteristics of pregnant women Period of observation: January 1999-May 2001 n= 78 patients 15 patients:IDU 28 patients: HES 35 patients: Pattern II

  6. Pregnant Patients from Pattern-II-countries (n=35)Countries of origin of the children fathers • 17/35 with a German husband/boyfriend • HIV-test 6/17 : 1/6 HIV-positive • 18/35 with a husband/boyfriend from the same mother-country • HIV-test 7/18 : 1/7 HIV-positive

  7. Frankfurt HIV-Cohort:Prophylaxis of vertical transmission &HAART during pregnancy • high risk for transmission: 10 pts. • HAART: 24 pts. • prophylaxis : 23 pts. 24 23 10 Period of observation January 1999-May 2001 n= 57 patients

  8. Frankfurt HIV-Cohort:Prophylaxis of vertical transmission (n=23) • Combivir: 21 patients • Retrovir: 2 patients

  9. Frankfurt HIV-Cohort:Prophylaxis of vertical transmission high risk patients (n=10) • NRTI´s plus NNRTI (n=9) • NRTI´s (n=1)

  10. Frankfurt HIV-Cohort:HAART of pregnant women(n=24) • NRTI´s plus PI 10 patients • NRTI´s plus NNRTI 14 patients

  11. HIV & pregnancy:Improvement in quality • German-Austrian Recommendations for the Treatment of HIV-positive Pregnant Women • Resistence testing • Pharmacokinetics • Documentation & publication

  12. Frankfurt HIV-Cohort:Management of pregnant women from Pattern-II-countries • First positive HIV-test during pregnancy (all: 18/78; migrants: 12/35) • Communication problems • Social and/or political situation • Isolation • Lost-to-follow-up after delivery

  13. Frankfurt HIV-Cohort:Management of pregnant IDU´s • Comorbidity • Lack of compliance • Ongoing use of illegal drugs • Social problems • Lost-to-follow-up after delivery

  14. Frankfurt HIV-Cohort:Management of HIV & PregnancyResults observational period I/1999-V/2001; n=57 • no case of vertical transmission of HIV • 1 case of transmission of HCV (12 pregnant women coinfected with hepatitis C)

  15. Management of HIV & Pregnancy Medical care mother Social work Political duty Medical care child

  16. haberla@hivcenter.de

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