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A Draft I mmunotoxicity V ocabulary for ToxRefDB

A Draft I mmunotoxicity V ocabulary for ToxRefDB. Bob Luebke Cardiopulmonary and Immunotoxicology Branch NHEERL, ORD, US EPA. ToxRefDB Vocabulary. 8834 rows, endpoints for cancer, developmental and reproductive toxicity

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A Draft I mmunotoxicity V ocabulary for ToxRefDB

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  1. A Draft Immunotoxicity Vocabulary for ToxRefDB Bob Luebke Cardiopulmonary and Immunotoxicology Branch NHEERL, ORD, US EPA

  2. ToxRefDB Vocabulary 8834 rows, endpoints for cancer, developmental and reproductive toxicity Endpoints selected to describe effects, based on toxicity data from testing hundreds of chemicals In rats and rabbits (http://actor.epa.gov/toxrefdb/faces/BasicInfo.jsp) Search by endpoint (study type, species, effect type) to return list of chemicals associated with effect (http://actor.epa.gov/toxrefdb/faces/SearchByEndpoint.jsp)

  3. Immunotoxicity Classification Immunosuppression (immunostimulation) Allergic hypersensitivity Autoimmunity Endpoints are relevant for adult and developmental exposure effects

  4. Immunotox Endpoint Interpretation Specificity,Complexity

  5. Draft immunotox vocabulary content Borrowed entries from exiting ToxRefDB that may indicate immune system effects Added new categories, subcategories endpoint classes and subclasses, effect types and targets that may be generated in immunotoxicity studies

  6. ToxRefDB Itox Vocabulary

  7. Next Steps and Caveats Incorporate into ToxRefDB Test ability to capture immunotox data in published studies Minimal outside input on entries Is the structure adaptable to other vocabularies?

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