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CYP2B6 Polymorphisms

About CYP2B6. Located on chromosome 19Makes up about 2-10% of hepatic CYP contentAlso expressed in brain (significantly higher in smokers and alcoholics)Metabolizes 4% of the top 200 drugs Highly inducible (some substrates also autoinduce, and it is also inducible in stressed conditions, e.g. fa

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CYP2B6 Polymorphisms

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    1. CYP2B6 Polymorphisms Emerald Murrell PharmD Candidate 2011 8/27/10

    2. About CYP2B6 Located on chromosome 19 Makes up about 2-10% of hepatic CYP content Also expressed in brain (significantly higher in smokers and alcoholics) Metabolizes 4% of the top 200 drugs Highly inducible (some substrates also autoinduce, and it is also inducible in stressed conditions, e.g. fasting) High interindividual variation

    3. Substrates

    4. Inhibitors and Inducers of 2B6

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