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A brief look at. Psychoneuroimmunology and HIV Phil Kucab Mind-Body Medicine. the psyche, the neuroendocrine system and the immune system.
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A brief look at Psychoneuroimmunology and HIV Phil Kucab Mind-Body Medicine the psyche, the neuroendocrine system and the immune system
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The goal is to stay as healthy as possible as long as possible
HIV positive people? 1 How do we measure health status in Viral Load = speed of train CD4+ T-Cell Count = track remaining
Finding out you are HIVpositiveisstressful 7
Is depression associated with more rapid HIVprogression? 38% greater loss Burack, JAMA, 1993 of CD4+ T-cells/year were more likely to Lyketsos, JAMA, 1993 Men with more symptoms be depressed
StressfulLife Events. Progression to AIDSand 8
? Is there a biological basis
“Slow HIV progression is correlated with low CCR5receptor density.” 10 “norepinephrine enhanced replication of both CCR5in vitro via chemokine receptor up-regulationand enhanced viral gene expression” 3
“To the extent that one’s medical condition and/or by stress, symptoms are caused or made worse we can help.” Herbert Benson, MD Benson-Henry Institute for Mind-Body Medicine
Most frequently used alternativeand complementarytherapies 5
Non-exercise control showed significant increases in anxiety and depressionas well as decreases in their NK cell count 5
Those in the exercise treatment group showed no similar changes and showed a significant increase in CD4+ Lymphocyte levels. 5
Prayerhas been clinically examined in an HIV-negative cohort with regard to self-esteem, anxiety, depression and showed significant improvement in 11 outcome measures. (O’Laire, 1997) The majority HIV+ participants increase their practice of prayer since their HIV diagnosis. 5
Massage boosts immune system function by: • Reducing anxiety and stress• Increasing white blood cell counts• Decreasing levels of cortisol • Activating natural killer cells
Reframing challenges may not change reality, but it can change attitude.