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Therapeutic approaches to hypopigmentation disorder Dr. Oussama Al Haj-Hussein, Syria

Therapeutic approaches to hypopigmentation disorder Dr. Oussama Al Haj-Hussein, Syria. Hipopigmentation is a lake of pigment in the skin It can be Definitive Albinism or Temporary After Kriotherapy. Hypopigmentation could be acquired Vitiligo. Or congenetal Piebaldism.

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Therapeutic approaches to hypopigmentation disorder Dr. Oussama Al Haj-Hussein, Syria

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  1. Therapeutic approaches to hypopigmentation disorderDr. Oussama Al Haj-Hussein, Syria

  2. Hipopigmentation is a lake of pigment in the skin It can be DefinitiveAlbinismor TemporaryAfter Kriotherapy

  3. Hypopigmentation could be acquiredVitiligo

  4. Or congenetalPiebaldism

  5. Hipopigmentation can be generalizedAlbinism

  6. Or localizedVitiligo

  7. The colour of skin Normal skin colour is dependent on hemoglobin, carotenoids and melanin pigment. the major colour determinant is melanin.

  8. Most of these disorders are related to the function of Melanocyte, the cell responsible of producing melanin, the major colour determinant.

  9. Melanocyte is very sensitive towards a lot of effects Medicaments (phenobarbital) Detergent (Phenol) Chemicals (Monobenzyl) Physical effects (Temperature)

  10. Hypomelanotic areas occur following the resolution of (T cell Lymphoma) Pityriasis Lichenoide

  11. It may occur in the superficial fungal infection (mistaken for Vitiligo)Pityriasis versicolor

  12. In inflammatory disorders of the skin there are areas of HypomelanosisScleroderma

  13. Hypopigmentation is seen inSarcoidosis

  14. Hypopigmentation is seen inLeprosy

  15. Hypopigmentation is seen inSyphilis

  16. Amelanosis is when there is a total lack of melanin in the skinAlbinism

  17. Leukoderma is a white skin and can be due to a variety of etiological factorsKeratoderma

  18. Both allergic and irritant dermatitis can produce secondary LeucodermaAtopic Dermatitis

  19. Treatment Treatment depends first on removing the effective agent when possible. (Medicaments, Detergent, Chemicals..)

  20. Treatment of Albinism No treatment is possible other than prescribing photoprotective creams

  21. Treatment of Vitiligo • The treatment of vitiligo is unsatisfactory • and in most cases the patient is advised to • Seek effective cosmetic camouflage for the lesions on exposed skin.

  22. Sunscreens In sunny climates, the prescription of sunscreens is often necessary

  23. Photoprotection by Sunscreens Benzylidine campher Dibenzoyl methan Benzophenones Benzimidazoles Cinnamates PABA

  24. PUVA Therapy Treatment with Systemic Psoralens combined with exposure to sunlight or to UVA light is effective in some cases Therapy is continued for at least 6 months, and in some for several years.

  25. Narrow band UVB It is more effective than PUVA Therapy

  26. Topical Psoralens The use of topical applications of Psoralens is hazardous and may result in untoward blistering of the skin

  27. Topical corticosteroid In some patient, the more potent topical corticosteroid preparations are effective but often at the price of some atrophy.

  28. Skin-bleaching creams In those patients with extensive Vitiligo and Only a few areas of hyperpigmentation skin–bleaching creams, such as hydroquinone are of use, under the risk of skin cancer !

  29. Grafting The use of grafting techniques minigrafts and autologous cultured melanocytes is interesting

  30. New therapy (Vitix) Vitix is a new, innovative topical treatment for Vitiligo with results ranging among the most effective, and without any reported side-effects, It is a combination of Catalase and Superoxide Dismutase.

  31. The Syrian Society of VitiligoArabic English Reviews

  32. SyriaUgarit (The first alphabet in the world)

  33. Thank you

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