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Four possible effects of a ligand on a channel. L2. L1. Closed 1. Closed 0. Open. 1. L4. L3. SOICR, CICR. L2. Closed. Open. Depletion-dependent termination. 2. L1. Closed 1. Closed 0. Open. 3b. 3a. CDI. 4. Channel block. Allosteric closing. Closed 1. Closed 0. Open.

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  1. Four possible effects of a ligand on a channel L2 L1 Closed 1 Closed 0 Open 1 L4 L3 SOICR, CICR L2 Closed Open Depletion-dependent termination 2 L1 Closed 1 Closed 0 Open

  2. 3b 3a CDI 4 Channel block Allosteric closing Closed 1 Closed 0 Open Open-bound Closed-bound Open Closed L3 L4 L4 L4 Open Closed

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