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miRNA :

miRNA :. microRNA. siRNA :. small interfering RNA. https:// openi.nlm.nih.gov / detailedresult.php?img =PMC3395882_fgene-03-00132-g001&req=4.

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miRNA :

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  1. miRNA: microRNA siRNA: small interfering RNA

  2. https://openi.nlm.nih.gov/detailedresult.php?img=PMC3395882_fgene-03-00132-g001&req=4https://openi.nlm.nih.gov/detailedresult.php?img=PMC3395882_fgene-03-00132-g001&req=4 Figure 1: (A)miRNA biogenesis begins in the nucleus where Drosha and DGCR8 cleave the primary RNA resulting in a miRNA precursor that is exported to the cytoplasm by Exportin5 and Ran-GTP61 where it is then processed by Dicer and TRBP. Next, the mature miRNA duplex is incorporated to the RISC where it is cleaved Dicer, associates with AGO2, and subsequently binds to the 3′ UTR of a target RNA leading to either mRNA degradation or translational repression. (B) Similarly, siRNA biogenesis depends on Dicer activity and incorporation into the RISC, however siRNAs avoid cleavage by Drosha as they are derived from exogenous viral or endogenous double-stranded RNA molecules mostly within the cytoplasm. Given the specificity of base pairing, the final outcome of the siRNA interference is the cleavage and degradation of their target mRNAs.

  3. miRNA, mirtron and siRNA biogenesis in Drosophila http://bio.usm.my/index.php?catid=0&id=149

  4. Domain organization of eukaryotic RNase III enzymes

  5. Pre-mRNA splicing

  6. Systematic Evolution of Ligands by EXponential enrichment)

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