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Eric J. Kunkel, et al . ASSAY and Drug Development Technologies Vol 2, Num 4, 2004

Rapid Structure-Activity and Selectivity Analysis of Kinase Inhibitors by BioMAP Analysis in Complex Human Primary Cell-Based Models. Eric J. Kunkel, et al . ASSAY and Drug Development Technologies Vol 2, Num 4, 2004 Presented by Ankit Garg. The Problem.

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Eric J. Kunkel, et al . ASSAY and Drug Development Technologies Vol 2, Num 4, 2004

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  1. Rapid Structure-Activity and Selectivity Analysis of Kinase Inhibitors by BioMAP Analysis in Complex Human Primary Cell-Based Models Eric J. Kunkel, et al. ASSAY and Drug Development Technologies Vol 2, Num 4, 2004 Presented by Ankit Garg

  2. The Problem • Protein kinases are attractive drug targets because of their central role in controlling signaling pathways in all cells. • Kinase inhibitors tend to interact with the ATP-binding pocket and thus tend to inhibit multiple targets.

  3. BioMAP Process

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